Медицинская библиотека · bioRxiv : the preprint server for biology · 2026

Topographic structure and function of locus coeruleus norepinephrine neurons.

Su Zhixiao, Kosillo Polina, Jung Kanghoon, Chen Shuonan, Summers Mathew T, Piet Alex, Hou Han, Hagihara Kenta M, Friedmann Drew, Ho-Shing Olivia, Becker Matthew I, Chartrand Thomas, Grotz Peter, Hilton-VanOsdall Ella, Lee Margaret, Javeri Rajvi, Tuggle Samantha L, Ouellette Naveen, Myers Holly, Laiton Camilo, Wulf Kaelin, Rohde John, Buccino Alessio P, Arshadi Cameron, Wang Di, Seshamani Sharmishtaa, Vasquez Sonya, Eng Carolyn M, Ollerenshaw Douglas R, Dee Nick, Casper Tamara, Ho Windy, Jungert Matthew, Jordan Atlas, Phillips Elliot, Chakka Anish Bhaswanth, Nasirova Kamiliam, Blake Krista, McCutcheon Audrey, Koch Megan, Vergara Maria Camila, Smith Kimberly A, Jarsky Tim, Lusk Nicholas, Rue Mara C P, Chen Xiaoyin, Siegle Joshua H, Glaser Adam K, Lee Brian R, Svoboda Karel, Isogai Yoh, Chandrashekar Jayaram V, Cohen Jeremiah Y

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Аннотация

Norepinephrine (NE) is released throughout most of the central nervous system by neurons in the locus coeruleus (LC). We found a relationship between the morphologies, gene expression, and activity of LC-NE neurons in mice. Axonal projections of individual neurons were extensive but largely confined to subsets of brain regions. Axonal projections and graded gene expression correlated with locations of cell bodies in LC. In a behavioral task requiring ongoing learning from actions, neurons in dorsal LC projecting to the cerebral cortex were excited when mice made a different choice from the previous one and by reward prediction errors, a signal driving learning. Background activity of neurons in ventral LC was higher when mice ignored stimuli indicating potential reward availability. These observations reveal a topographically organized structure and function of a neurotransmitter system and show that it contains learning signals for flexible behavior.

Для цитирования: Su Zhixiao, Kosillo Polina, Jung Kanghoon, Chen Shuonan, Summers Mathew T, Piet Alex, Hou Han, Hagihara Kenta M, Friedmann Drew, Ho-Shing Olivia, Becker Matthew I, Chartrand Thomas, Grotz Peter, Hilton-VanOsdall Ella, Lee Margaret, Javeri Rajvi, Tuggle Samantha L, Ouellette Naveen, Myers Holly, Laiton Camilo, Wulf Kaelin, Rohde John, Buccino Alessio P, Arshadi Cameron, Wang Di, Seshamani Sharmishtaa, Vasquez Sonya, Eng Carolyn M, Ollerenshaw Douglas R, Dee Nick, Casper Tamara, Ho Windy, Jungert Matthew, Jordan Atlas, Phillips Elliot, Chakka Anish Bhaswanth, Nasirova Kamiliam, Blake Krista, McCutcheon Audrey, Koch Megan, Vergara Maria Camila, Smith Kimberly A, Jarsky Tim, Lusk Nicholas, Rue Mara C P, Chen Xiaoyin, Siegle Joshua H, Glaser Adam K, Lee Brian R, Svoboda Karel, Isogai Yoh, Chandrashekar Jayaram V, Cohen Jeremiah Y. Topographic structure and function of locus coeruleus norepinephrine neurons.. bioRxiv : the preprint server for biology. 2026. DOI: 10.64898/2026.04.10.717727.

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