RAPID LOW-COST DETECTION OF TYPE 2CALR MUTATION BY ALLELE-SPECIFIC RT-PCR FOR DIAGNOSIS OF MYELOPROLIFERATIVE NEOPLASMS.

Automated insulin delivery (AID) systems have become a standard of care in type 1 diabetes and are increasingly used across all age groups, including during pregnancy. As their utilization expands, clinicians more often encounter patients using AID systems in perioperative and peripartum settings. However, guidance regarding continuation of AID therapy during procedures under anesthesia / sedation or during labor remains limited. This document provides practical, consensus‑based recommendations for the use of AID systems during minor procedures, selected major surgeries, and throughout labor and delivery, aiming to support anesthesiologists, surgeons, and other procedural specialists as well as obstetric teams and diabetes specialists in clinical decision‑making. Eleven experts in pediatric and adult diabetology, each with extensive clinical experience in managing AID users in outpatient and inpatient settings, conducted a comprehensive literature review and synthesized available evidence with collective clinical experience. The authors outline criteria for continuation of AID therapy during procedures, including requirements related to the patient, procedural team, and type of procedure. Detailed perioperative algorithms are provided. Recommendations for labor emphasize adjustments of AID parameters, target glucose levels, and postpartum modifications. While AID system use may be continued during many minor procedures and selected major surgeries, intravenous insulin therapy remains preferable in situations associated with hemodynamic instability or high metabolic risk. With appropriate preparation and interdisciplinary coordination, continuation of AID therapy during selected procedures and childbirth can be safe and effective, reducing glycemic variability and treatment burden. As evidence remains limited, further clinical studies are urgently needed to validate and refine these recommendations.