Molecular communication system using Zn2+ selective supramolecular nanochannel to induce photoregulated catalysis.

We developed synthetic ionophores that self-assemble into supramolecular nanochannels for the transport of Zn2+ across lipid bilayers. The translocated Zn2+ forms a photoactive PPIX-Zn2+ complex that generates 1O2 to oxidize tryptophan, establishing a Zn2+-mediated cascade reaction network within confined spaces, which is crucial for developing photoregulated molecular communication systems.