Journal of thoracic disease · 2025
Postoperative routine computed tomography allows detection of early-stage acute exacerbations of interstitial pneumonia.
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Seto Katsutoshi, Ishikawa Yuya, Kimura Koichiro, Adachi Takuya, Asakawa Ayaka, Kobayashi Masashi, Ishibashi Hironori, Tateishi Ukihide, Okubo Kenichi
Аннотация
BACKGROUND: Postoperative acute exacerbation of interstitial pneumonia (IP-AE) is highly lethal after lung resection. Whether a symptom-free, routine computed tomography (rCT) can detect IP-AE early enough to justify pre-emptive steroids is unknown. We therefore aimed to assess the diagnostic accuracy of early postoperative rCT for detecting clinical IP-AE (cIP-AE) and to identify a high-specificity rCT score threshold that could support pre-emptive steroid treatment.
METHODS: This single-center, retrospective diagnostic-accuracy study analyzed 120 consecutive lung-cancer patients with underlying interstitial pneumonia (IP) who underwent high-resolution rCT within 7 days after surgery. Eligibility was based on preoperative high-resolution computed tomography (HRCT) demonstrating IP, irrespective of postoperative pathological confirmation. Two thoracic radiologists independently graded each scan on a five-point likelihood scale; a summed 10-point score (range, 2-10) was defined as the sum of the two readers' five-point ratings, assigned retrospectively. Diagnostic accuracy was expressed as sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). The ROC analysis assessed the ability of the rCT score to detect cIP-AE. For analysis, the proposed treatment threshold was the lowest score, giving 100% specificity.
RESULTS: IP-AE developed in 14 patients (11.6%). The ROC for cIP-AE detection yielded an AUC of 0.956. A summed score ≥9 achieved 100% specificity and detected 36% of presymptomatic events, whereas ≥6 increased sensitivity (86%) but lowered specificity (89%). Five patients received steroid pulse therapy solely on the basis of rCT; four of the five scans scored ≥9 and one scored 8. Thirty- and 90-day mortality were 0.8% and 3.3%, respectively, and no grade ≥3 steroid-related toxicity occurred.
CONCLUSIONS: A single rCT obtained within 1 week of lung resection can reveal radiological IP-AE (rIP-AE) before clinical decline. Using a score ≥9 confines early steroid treatment to patients with near-certain disease, avoiding unnecessary exposure. Prospective studies should confirm whether this high-specificity strategy improves survival and resource utilization.
METHODS: This single-center, retrospective diagnostic-accuracy study analyzed 120 consecutive lung-cancer patients with underlying interstitial pneumonia (IP) who underwent high-resolution rCT within 7 days after surgery. Eligibility was based on preoperative high-resolution computed tomography (HRCT) demonstrating IP, irrespective of postoperative pathological confirmation. Two thoracic radiologists independently graded each scan on a five-point likelihood scale; a summed 10-point score (range, 2-10) was defined as the sum of the two readers' five-point ratings, assigned retrospectively. Diagnostic accuracy was expressed as sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). The ROC analysis assessed the ability of the rCT score to detect cIP-AE. For analysis, the proposed treatment threshold was the lowest score, giving 100% specificity.
RESULTS: IP-AE developed in 14 patients (11.6%). The ROC for cIP-AE detection yielded an AUC of 0.956. A summed score ≥9 achieved 100% specificity and detected 36% of presymptomatic events, whereas ≥6 increased sensitivity (86%) but lowered specificity (89%). Five patients received steroid pulse therapy solely on the basis of rCT; four of the five scans scored ≥9 and one scored 8. Thirty- and 90-day mortality were 0.8% and 3.3%, respectively, and no grade ≥3 steroid-related toxicity occurred.
CONCLUSIONS: A single rCT obtained within 1 week of lung resection can reveal radiological IP-AE (rIP-AE) before clinical decline. Using a score ≥9 confines early steroid treatment to patients with near-certain disease, avoiding unnecessary exposure. Prospective studies should confirm whether this high-specificity strategy improves survival and resource utilization.