Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2003
Imported Lassa fever in Germany: surveillance and management of contact persons.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Haas Walter H, Breuer Thomas, Pfaff Günter, Schmitz Herbert, Köhler Päivi, Asper Marcel, Emmerich Petra, Drosten Christian, Gölnitz Uta, Fleischer Klaus, Günther Stephan
Аннотация
This study sought to assess the risk of secondary transmission after import of Lassa fever into Europe. A total of 232 persons exposed to a case of Lassa fever imported into Germany were identified. The level of exposure was determined for 157 persons (68%), and 149 (64%) were tested serologically. High-risk or close contact was reported by 30 (19%) of 157 persons. No symptomatic secondary infections were observed. However, Lassa virus-specific immunoglobulin G antibodies were detected in a serum sample obtained from a physician who examined the index patient on day 9 of illness. The physician received ribavirin prophylaxis and did not develop symptoms of Lassa fever. On the basis of these data, the contact was classified as having a probable secondary infection. The study indicates a low risk of transmission during the initial phase of symptomatic Lassa fever, even with high-risk exposures. The risk may increase with progression of disease and increasing virus load.