Journal of vascular research · 2026
Effects of Exercise Mode and Intensity on Retinal Microvascular Structure and Function in Heart Failure Patients with Preserved Ejection Fraction: A Pilot Exercise Intervention Trial.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Streese Lukas, Ritter Egbert Thomas, Schoch Raphael, Kröpfl Julia Maria, Hauser Christoph, Gasser Benedikt, Dieterle Thomas, Schmidt-Trucksäss Arno, Hanssen Henner
Аннотация
INTRODUCTION: We aimed to investigate the effect of different exercise modes on retinal microvascular endothelial function in patients with HF with preserved ejection fraction (HFpEF).
METHODS: Twenty-eight patients were randomly allocated to either a moderate (MCT) or high-intensity interval training (HIIT) group for 12 weeks. Retinal microvascular structure and function were investigated by analyzing central retinal arteriolar (CRAE) and venular (CRVE) diameter equivalents, the arteriolar-to-venular diameter ratio (AVR), and the dynamic arteriolar (aFID) and venular (vFID) flicker light-induced dilation response.
RESULTS: Twenty patients (mean age 70 ± 9 years) were included in the final analysis. After HIIT, AVR increased (0.80 ± 0.03 vs. 0.83 ± 0.04, p = 0.03) due to arteriolar widening. CRAE increased (157 ± 18 µm vs. 164 ± 18 µm, p = 0.05), but CRVE did not change (196 ± 27 µm vs. 197 ± 24 µm, p = 0.56). After MCT, AVR also increased (0.80 ± 0.08 vs. 0.83 ± 0.06, p = 0.02) without significant changes in CRAE (160 ± 19 µm vs. 165 ± 18 µm, p = 0.07) or CRVE (201 ± 14 µm vs. 199 ± 14 µm, p = 0.40). aFID improved after MCT (2.1 ± 1.6% vs. 3.1 ± 1.8%, p = 0.03) but not after the HIIT intervention (2.1 ± 1.7% vs. 2.4 ± 2.1%, p = 0.60). vFID did not statistically significant change neither in the HIIT (4.4 ± 2.2% vs. 3.4 ± 1.9%, p = 0.06) nor in the MCT (4.3 ± 2.2% vs. 5.5 ± 4.1%, p = 0.26) group.
CONCLUSION: MCT and HIIT are both adequate therapy options to improve microvascular health in patients with HFpEF.
METHODS: Twenty-eight patients were randomly allocated to either a moderate (MCT) or high-intensity interval training (HIIT) group for 12 weeks. Retinal microvascular structure and function were investigated by analyzing central retinal arteriolar (CRAE) and venular (CRVE) diameter equivalents, the arteriolar-to-venular diameter ratio (AVR), and the dynamic arteriolar (aFID) and venular (vFID) flicker light-induced dilation response.
RESULTS: Twenty patients (mean age 70 ± 9 years) were included in the final analysis. After HIIT, AVR increased (0.80 ± 0.03 vs. 0.83 ± 0.04, p = 0.03) due to arteriolar widening. CRAE increased (157 ± 18 µm vs. 164 ± 18 µm, p = 0.05), but CRVE did not change (196 ± 27 µm vs. 197 ± 24 µm, p = 0.56). After MCT, AVR also increased (0.80 ± 0.08 vs. 0.83 ± 0.06, p = 0.02) without significant changes in CRAE (160 ± 19 µm vs. 165 ± 18 µm, p = 0.07) or CRVE (201 ± 14 µm vs. 199 ± 14 µm, p = 0.40). aFID improved after MCT (2.1 ± 1.6% vs. 3.1 ± 1.8%, p = 0.03) but not after the HIIT intervention (2.1 ± 1.7% vs. 2.4 ± 2.1%, p = 0.60). vFID did not statistically significant change neither in the HIIT (4.4 ± 2.2% vs. 3.4 ± 1.9%, p = 0.06) nor in the MCT (4.3 ± 2.2% vs. 5.5 ± 4.1%, p = 0.26) group.
CONCLUSION: MCT and HIIT are both adequate therapy options to improve microvascular health in patients with HFpEF.