Frontiers in cardiovascular medicine · 2025
Effects of high-intensity interval training on cardiopulmonary function and quality of life in patients with myocardial infarction: a meta-analysis.
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Xu Xiening, Shen Ying, Lao Yuying
Аннотация
BACKGROUND: High-intensity interval training (HIIT) is increasingly used in cardiac rehabilitation. Its effects on cardiopulmonary function and quality of life in patients with myocardial infarction (MI) require systematic evaluation.
METHODS: A systematic search was conducted in PubMed, Embase, Web of Science, Cochrane Central, and CNKI from inception to April 1, 2025. Randomized controlled trials assessing the effects of HIIT on peak heart rate (HRpeak), peak oxygen uptake (VO₂peak), respiratory exchange ratio (RER), and quality of life (QOL) in post-MI patients were included. Data were synthesized using a random-effects model. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the I² statistic, and sensitivity analyses were performed.
RESULTS: Nine trials with 508 participants were included. HIIT did not significantly affect HRpeak (SMD = -0.20; 95% CI: -1.10 to 0.70; I2 = 62.4%) or VO₂peak (SMD = 0.32; 95% CI: -0.07 to 0.71; I2 = 69.1%). RER was significantly reduced in the HIIT group (SMD = -1.26; 95% CI: -1.54 to -0.98; I2 = 0%). No significant improvement was observed in QOL (SMD = 0.07; 95% CI: -0.37 to 0.50; I2 = 0%). Sensitivity analyses suggested that individual studies contributed to heterogeneity in HRpeak and VO₂peak outcomes.
CONCLUSIONS: HIIT may influence selected cardiopulmonary indicators in post-MI patients, particularly metabolic efficiency. Its effects on exercise capacity and quality of life remain uncertain. Further research with standardized protocols is needed.
METHODS: A systematic search was conducted in PubMed, Embase, Web of Science, Cochrane Central, and CNKI from inception to April 1, 2025. Randomized controlled trials assessing the effects of HIIT on peak heart rate (HRpeak), peak oxygen uptake (VO₂peak), respiratory exchange ratio (RER), and quality of life (QOL) in post-MI patients were included. Data were synthesized using a random-effects model. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed with the I² statistic, and sensitivity analyses were performed.
RESULTS: Nine trials with 508 participants were included. HIIT did not significantly affect HRpeak (SMD = -0.20; 95% CI: -1.10 to 0.70; I2 = 62.4%) or VO₂peak (SMD = 0.32; 95% CI: -0.07 to 0.71; I2 = 69.1%). RER was significantly reduced in the HIIT group (SMD = -1.26; 95% CI: -1.54 to -0.98; I2 = 0%). No significant improvement was observed in QOL (SMD = 0.07; 95% CI: -0.37 to 0.50; I2 = 0%). Sensitivity analyses suggested that individual studies contributed to heterogeneity in HRpeak and VO₂peak outcomes.
CONCLUSIONS: HIIT may influence selected cardiopulmonary indicators in post-MI patients, particularly metabolic efficiency. Its effects on exercise capacity and quality of life remain uncertain. Further research with standardized protocols is needed.