Annales pharmaceutiques francaises · 2025
Impact of metabolic syndrome on health-related quality of life and its determinants in post-myocardial infarction patients.
СтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Sheikh Anam Anwar, Padmanabha Hola Tejashree, Varghese Treesa P
Аннотация
INTRODUCTION: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. Health-related quality of life (HRQoL) is a key patient-reported outcome, especially in chronic conditions like myocardial infarction (MI). This study aimed to assess HRQoL and its determinants in post-MI patients with and without metabolic syndrome (MetS) using the EQ-5D-5L questionnaire.
METHODOLOGY: A cross-sectional observational study was conducted among 160 inpatients (aged 25-75years) with MI in a tertiary care hospital. Patients who were on mechanical ventilation, or those with psychiatric disorders, or cognitive impairment were excluded. MetS was diagnosed using the revised NCEP-ATP III criteria, and the QoL was assessed using EQ-5D-5L questionnaire.
RESULTS: Of the 160 participants, 66.3% were male. The mean age was 58.54±10.02years. The mean EQ-5D-5L index was 0.70±0.26, and the EQ-VAS score was 66.09±15.59. MetS was observed with 75.6% of the population; women were more likely to have it (79.6%) than men (73.6%). Descriptive analysis showed that the women reported lower QoL than men, irrespective of their MetS status. The study result shows that, highest EQ-VAS score was observed in men with MetS (70.06±14.63), while women without MetS had the lowest EQ-5D Index (0.580±0.250). However, gender, MetS, and their interaction were not significant predictors of HRQoL, while occupation was the only significant determinant in this study.
CONCLUSION: The occurrence of MetS in post-MI patients was very common, especially in women and those with concomitant conditions. Even if there are no significant impacts of gender or MetS on QoL after adjustment, MI recovery can be maximised through early detection and integrated risk management, which includes lifestyle changes and customised cardiac rehabilitation.
METHODOLOGY: A cross-sectional observational study was conducted among 160 inpatients (aged 25-75years) with MI in a tertiary care hospital. Patients who were on mechanical ventilation, or those with psychiatric disorders, or cognitive impairment were excluded. MetS was diagnosed using the revised NCEP-ATP III criteria, and the QoL was assessed using EQ-5D-5L questionnaire.
RESULTS: Of the 160 participants, 66.3% were male. The mean age was 58.54±10.02years. The mean EQ-5D-5L index was 0.70±0.26, and the EQ-VAS score was 66.09±15.59. MetS was observed with 75.6% of the population; women were more likely to have it (79.6%) than men (73.6%). Descriptive analysis showed that the women reported lower QoL than men, irrespective of their MetS status. The study result shows that, highest EQ-VAS score was observed in men with MetS (70.06±14.63), while women without MetS had the lowest EQ-5D Index (0.580±0.250). However, gender, MetS, and their interaction were not significant predictors of HRQoL, while occupation was the only significant determinant in this study.
CONCLUSION: The occurrence of MetS in post-MI patients was very common, especially in women and those with concomitant conditions. Even if there are no significant impacts of gender or MetS on QoL after adjustment, MI recovery can be maximised through early detection and integrated risk management, which includes lifestyle changes and customised cardiac rehabilitation.