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DOI 10.5603/cj.99973

Медицинская библиотека · Cardiology journal · 2025

Early treatment with inhibitors of P2Y12 receptor in patients with ST-segment elevation myocardial infarction - 2023 ESC recommendations and scientific evidence. Is clinical evidence sufficient to suggest a move towards precision medicine? The ELECTRA-SIRIO 2 investigators' viewpoint.

Kubica Jacek, Adamski Piotr, Badariene Jolita, Bonaca Marc, Buszman Piotr, Gabulova Rahima, Gajda Robert, Geisler Tobias, Gil Robert, Gorog Diana A, Gurbel Paul A, Hajdukiewicz Tomasz, Hudzik Bartosz, James Stefan, Jeong Young-Hoon, Kern Adam, Kochman Wacław, Kubica Aldona, Kuliczkowski Wiktor, Magielski Przemysław, Niezgoda Piotr, Ostrowska Małgorzata, Raggi Paolo, Rahimov Uzeyir, Skonieczny Grzegorz, Siller-Matula Jolanta M, Specchia Giuseppe, Szarpak Łukasz, Szymański Paweł, Tantry Udaya, Umińska Julia, Navarese Eliano Pio

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Аннотация

The 2023 ESC guidelines changed previously recommended a strategy of early treatment in patients with STEMI. Pre-treatment with a P2Y12 receptor inhibitor may be considered in patients undergoing a primary PCI strategy (Class IIb, Level of evidence B). However, the available scientific evidence justifies a personalized approach differentiating the indications for pre-treatment with oral P2Y12 receptor inhibitors depending on the concomitant administration of opioids. In our opinion, in patients undergoing primary PCI not treated with opioids, pre-treatment with an oral P2Y12 receptor inhibitor should be applied, while in patients undergoing primary PCI treated with opioids, pre-treatment with an oral P2Y12 receptor inhibitor should be considered.

Для цитирования: Kubica Jacek, Adamski Piotr, Badariene Jolita, Bonaca Marc, Buszman Piotr, Gabulova Rahima, Gajda Robert, Geisler Tobias, Gil Robert, Gorog Diana A, Gurbel Paul A, Hajdukiewicz Tomasz, Hudzik Bartosz, James Stefan, Jeong Young-Hoon, Kern Adam, Kochman Wacław, Kubica Aldona, Kuliczkowski Wiktor, Magielski Przemysław, Niezgoda Piotr, Ostrowska Małgorzata, Raggi Paolo, Rahimov Uzeyir, Skonieczny Grzegorz, Siller-Matula Jolanta M, Specchia Giuseppe, Szarpak Łukasz, Szymański Paweł, Tantry Udaya, Umińska Julia, Navarese Eliano Pio. Early treatment with inhibitors of P2Y12 receptor in patients with ST-segment elevation myocardial infarction - 2023 ESC recommendations and scientific evidence. Is clinical evidence sufficient to suggest a move towards precision medicine? The ELECTRA-SIRIO 2 investigators' viewpoint.. Cardiology journal. 2025. DOI: 10.5603/cj.99973.

Предметные рубрики MeSH

HumansST Elevation Myocardial InfarctionPurinergic P2Y Receptor AntagonistsPrecision MedicinePractice Guidelines as TopicPercutaneous Coronary InterventionTreatment OutcomePlatelet Aggregation Inhibitors
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