British journal of cancer · 2009
A population-based cohort study on sun habits and endometrial cancer.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Epstein E, Lindqvist P G, Geppert B, Olsson H
Аннотация
BACKGROUND: No large cohort study has examined the risk of endometrial cancer in relation to sun exposure.
METHODS: A population-based cohort study of 29,508 women who answered a questionnaire in 1990-92, of whom 24,098 responded to a follow-up enquiry in 2000-02. They were followed for an average of 15.5 years.
RESULTS: Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. We used a multivariate Cox regression analysis adjusting for age and other selected demographic variables to determine the risk of endometrial cancer. Women using sun beds >3 times per year reduced their hazard risk (HR) by 40% (0.6, 95% confidence interval (CI) 0.4-0.9) or by 50% when adjusting for body mass index or physical activity (HR 0.5, 95% CI 0.3-0.9), and those women who were sunbathing during summer reduced their risk by 20% (HR 0.8 95% CI 0.5-1.5) compared with women who did not expose themselves to the sun or to artificial sun (i.e., sun beds).
CONCLUSION: Exposure to artificial sun by the use of sun beds >3 times per year was associated with a 40% reduction in the risk of endometrial cancer, probably by improving the vitamin D levels during winter.
METHODS: A population-based cohort study of 29,508 women who answered a questionnaire in 1990-92, of whom 24,098 responded to a follow-up enquiry in 2000-02. They were followed for an average of 15.5 years.
RESULTS: Among the 17,822 postmenopausal women included, 166 cases of endometrial cancer were diagnosed. We used a multivariate Cox regression analysis adjusting for age and other selected demographic variables to determine the risk of endometrial cancer. Women using sun beds >3 times per year reduced their hazard risk (HR) by 40% (0.6, 95% confidence interval (CI) 0.4-0.9) or by 50% when adjusting for body mass index or physical activity (HR 0.5, 95% CI 0.3-0.9), and those women who were sunbathing during summer reduced their risk by 20% (HR 0.8 95% CI 0.5-1.5) compared with women who did not expose themselves to the sun or to artificial sun (i.e., sun beds).
CONCLUSION: Exposure to artificial sun by the use of sun beds >3 times per year was associated with a 40% reduction in the risk of endometrial cancer, probably by improving the vitamin D levels during winter.