Journal of affective disorders · 2004
The effect of bright light exposure on pupillary fluctuations in healthy subjects.
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Szabó Zoltán, Tokaji Zsolt, Kálmán János, Oroszi László, Pestenácz Anikó, Janka Zoltán
Аннотация
BACKGROUND: Light therapy is thought to be the first choice treatment of winter depression. However, its way of action is poorly understood. In order to find a solid effect of bright artificial light, we studied its possible alerting action through the spontaneous fluctuations of the pupil, considered to be an objective measurement of vigilance.
METHODS: Pupillary fluctuations of 10 healthy subjects (mean age: 22+/-1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35+/-4.4% S.E.M. The average pupillary diameters were unchanged (101+/-2.2% S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably.
LIMITATIONS: There was no dim light or other placebo control of the light treatment.
CONCLUSIONS: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.
METHODS: Pupillary fluctuations of 10 healthy subjects (mean age: 22+/-1 S.D. years) were measured for 60 s before and 15 min after 0.5 h, 10000-lux light exposure. The cumulative change in pupil size, characterised by the pupillary unrest index (PUI) decreased at each subject, and this decrease was in average 35+/-4.4% S.E.M. The average pupillary diameters were unchanged (101+/-2.2% S.E.M.). This analysis revealed that the slow components of the pupillary fluctuations also decreased considerably.
LIMITATIONS: There was no dim light or other placebo control of the light treatment.
CONCLUSIONS: Bright light exposure significantly influenced the pupillary fluctuations. We suppose that bright light exposure increases the level of alertness, and this could be a possible way by which bright artificial light exerts a beneficial effect also in affective disorders.