Anticancer research · 1999
Application of high energy shock waves to cancer treatment in combination with cisplatin and ATX-70.
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Maruyama M, Asano T, Nakagohri T, Uematsu T, Hasegawa M, Miyauchi H, Iwashita C, Isono K
Аннотация
BACKGROUND: The anti-tumor effects of high-energy shock waves (HESW) in combination with cisplatin (CDDP) and ATX-70, as a photosensitizer, were investigated in vitro and in vivo.
METHODS: Active oxygen generation by HESW was studied by means of electron spin resonance (ESR) system. The anti-tumor effects of HESW in combination with cisplatin (CDDP) and ATX-70 was investigated in vitro and in vivo.
RESULTS: HESW exposure induced singlet oxygen or hydroxyl radical. Adding ATX-70 enhanced the cell damage induced by HESW dose-dependently. Ascorbic acid inhibited the combined effect of HESW and ATX-70. Adding CDDP did not enhanced cell damage by HESW. The combined therapy of HESW, CDDP and ATX-70 showed further inhibition of tumor growth in vivo.
CONCLUSIONS: These results indicate that HESW activated ATX-70, and that the anti-tumor effect of HESW and ATX-70 was caused by active oxygen generation. HESW is able to be utilized with any other cancer treatment.
METHODS: Active oxygen generation by HESW was studied by means of electron spin resonance (ESR) system. The anti-tumor effects of HESW in combination with cisplatin (CDDP) and ATX-70 was investigated in vitro and in vivo.
RESULTS: HESW exposure induced singlet oxygen or hydroxyl radical. Adding ATX-70 enhanced the cell damage induced by HESW dose-dependently. Ascorbic acid inhibited the combined effect of HESW and ATX-70. Adding CDDP did not enhanced cell damage by HESW. The combined therapy of HESW, CDDP and ATX-70 showed further inhibition of tumor growth in vivo.
CONCLUSIONS: These results indicate that HESW activated ATX-70, and that the anti-tumor effect of HESW and ATX-70 was caused by active oxygen generation. HESW is able to be utilized with any other cancer treatment.
Предметные рубрики MeSH
AnimalsAntineoplastic Combined Chemotherapy ProtocolsAntioxidantsAscorbic AcidCisplatinCombined Modality TherapyElectron Spin Resonance SpectroscopyFree RadicalsHigh-Energy Shock WavesHydroxyl RadicalLiver Neoplasms, ExperimentalMaleMiceMice, Inbred C3HNeoplasm TransplantationOxidative StressOxygenPhotosensitizing AgentsPorphyrinsReactive Oxygen SpeciesSinglet OxygenTumor Cells, Cultured