Biomarkers in medicine · 2015
Clinical evaluation of the Heart Check system, a new quantitative measurement of fresh capillary BNP.
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Monfort Astrid, Da Silva Kelly, Vodovar Nicolas, Gayat Etienne, Cohen-Solal Alain, Manivet Philippe
Аннотация
AIM: We have evaluated here the clinical and analytical performance of the Alere™ Heart Check (AHC) test, a rapid point-of-care immunoassay designed for the measurement of BNP from fresh capillary whole blood.
PATIENTS & METHODS: One-hundred-and-sixty-three patients with stable chronic heart failure followed at the cardiac rehabilitation were submitted to simultaneous capillary (AHC) and plasma (Abbott architect system) BNP measurements.
RESULTS: Both methods showed a good correlation, although the values diverged when BNP was higher than 2000 pg/ml. Despite a relatively poor precision of AHC, however, both methods showed the same performances to assess patients' dyspnea and equivalent sensitivity, specificity, negative and positive predicting values.
CONCLUSION: AHC BNP test is a good POC for the management of heart failure despite a relatively poor precision.
PATIENTS & METHODS: One-hundred-and-sixty-three patients with stable chronic heart failure followed at the cardiac rehabilitation were submitted to simultaneous capillary (AHC) and plasma (Abbott architect system) BNP measurements.
RESULTS: Both methods showed a good correlation, although the values diverged when BNP was higher than 2000 pg/ml. Despite a relatively poor precision of AHC, however, both methods showed the same performances to assess patients' dyspnea and equivalent sensitivity, specificity, negative and positive predicting values.
CONCLUSION: AHC BNP test is a good POC for the management of heart failure despite a relatively poor precision.