Substance use & misuse · 2026
The Association Between Drug Craving and Suicidal Thoughts and Behavior in Chinese Male Methamphetamine Inpatients: The Mediating Effect of Depressive Symptoms.
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Zhang Xinyue, Haider Arsalan, Tian Yang, Jiang Linjun, Wang Dongmei, Zhang Xiang-Yang
Аннотация
BACKGROUND: Suicidal thoughts and behavior (STBs) are prevalent in patients with methamphetamine use disorder (MAUD). The present study aimed to examine the relationship between drug craving and STBs among Chinese MAUD inpatients, specifically focusing on the potential mediating role of depressive symptoms.
METHODS: After quality control, 538 inpatients with MAUD were included in the study. Inpatients were recruited from a drug rehabilitation center. Data were collected using the Desires for Drug Questionnaire (DDQ), the Beck Depression Inventory (BDI), and the STBs question.
RESULTS: Among MAUD inpatients, 7.6% exhibited STBs. Compared to those without STBs, patients with STBs had higher depressive symptoms scores, higher DDQ-negative reinforcement scores, and higher total DDQ scores. Significant positive associations were found among DDQ scores, depressive symptoms, and STBs. Mediation analysis indicated that the mediation effect of depressive symptoms was significant (mediation effect: 26%).
CONCLUSION: Depressive symptoms serve as a mediator in the relationship between drug craving and STBs in MAUD inpatients. These findings highlight the necessity of incorporating depressive symptoms screening and intervention into addiction treatment which may be related to a lower prevalence of suicide risk.
METHODS: After quality control, 538 inpatients with MAUD were included in the study. Inpatients were recruited from a drug rehabilitation center. Data were collected using the Desires for Drug Questionnaire (DDQ), the Beck Depression Inventory (BDI), and the STBs question.
RESULTS: Among MAUD inpatients, 7.6% exhibited STBs. Compared to those without STBs, patients with STBs had higher depressive symptoms scores, higher DDQ-negative reinforcement scores, and higher total DDQ scores. Significant positive associations were found among DDQ scores, depressive symptoms, and STBs. Mediation analysis indicated that the mediation effect of depressive symptoms was significant (mediation effect: 26%).
CONCLUSION: Depressive symptoms serve as a mediator in the relationship between drug craving and STBs in MAUD inpatients. These findings highlight the necessity of incorporating depressive symptoms screening and intervention into addiction treatment which may be related to a lower prevalence of suicide risk.