Relationship among Sleep Disturbance, Stress, and Suicidal Ideation in Clinical High Risk for Psychosis.
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Wastler Heather M, Moe Aubrey, Blouin Alexandra M, Bozzay Melanie, Kilicoglu Melissa F V, Arango Celso, Bouix Sylvain, Broome Matthew R, Calkins Monica E, Conus Philippe, Corcoran Cheryl M, Crawford Courtney, Diaz-Caneja Covadonga M, Damiani Stefano, Fusar-Poli Paolo, Keshavan Matcheri S, Mittal Vijay A, Nguyen Josh, Schiffman Jason, Shah Jai L, Yassin Walid, Yung Alison, Addington Jean, Alameda Luis, Cadenhead Kristin S, Carrion Ricardo E, Castillo-Passi Rolando I, Chen Eric Yu Hai, Choi Jimmy, Cornblatt Barbara A, Ellman Lauren M, Gaspar Pablo A, Gerber Carla, Glenthøj Louise Birkedal, Horton Leslie E, Hui Christy Lai Ming, Kambeitz Joseph, Kambeitz-Ilankovic Lana, Kim Minah, Kim Sung-Wan, Koutsouleris Nikolaos, Kwon Jun Soo, Langbein Kerstin, Mamah Daniel, Mathalon Daniel H, Nordentoft Merete, Pearlson Godfrey D, Perez Jesus, Perkins Diana O, Powers Iii Albert R, Rogers Jack, Sabb Fred W, Silverstein Steven M, Smesny Stefan, Stone William S, Strauss Gregory P, Thompson Judy L, Upthegrove Rachel, Verma Swapna, Wang Jijun, Wolf Daniel H, Zhang Tianhong, Pasternak Ofer, Kahn Rene S, Shenton Martha E, McGorry Patrick D, Nelson Barnaby, Kane John M, Bearden Carrie E, Woods Scott W, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ), Breitborde Nicholas, Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ)
Аннотация
STUDY DESIGN: The current study used data generated by the Accelerating Medicines Partnership® Schizophrenia Observational Study. The total sample included 1,048 participants (827 CHR and 221 community controls). Participants completed measures of suicidal ideation/attempts, attenuated positive symptoms, depressive symptoms, perceived stress, and sleep disturbance.
STUDY RESULTS: Results supported a relationship between sleep disturbance and suicidal ideation/attempts in CHR, with participants who had lifetime ideation and attempts experiencing more sleep disturbance than those with no ideation or attempts. We also found small, but significant positive correlations between sleep disturbance and suicide risk in CHR. When accounting for other variables in the model, the effect of sleep disturbance remained significant for past month ideation, but not lifetime ideation or attempts. Both interaction models were non-significant.
CONCLUSIONS: Our findings highlight the potential value of sleep measures in early identification and treatment of suicide risk in CHR. Further research in this area is warranted.