medRxiv : the preprint server for health sciences · 2026

Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.

СтатьяПрепринтНазвание и аннотация: Перевод в очереди

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Wan Bin, Larivière Sara, Moreau Clara A, Warrier Varun, Bethlehem Richard A I, Fan Yun-Shuang, He Yuankai, Agartz Ingrid, Nerland Stener, Jönsson Erik G, Cobia Derin, Wang Lei, Facorro Benedicto Crespo, Romero-Garcia Rafael, Segura Patricia, Banaj Nerisa, Vecchio Daniela, Van Rheenen Tamsyn, Sumner Philip James, Ringin Elysha, Rossell Susan, Carruthers Sean, Sumner Philip J, Woods Will, Hughes Matthew, Donohoe Gary, Corley Emma, Schall Ulrich, Henskens Frans, Scott Rodney, Michie Patricia, Loughland Carmel, Rasser Paul, Cairns Murray, Mowry Bryan, Catts Stanley, Pantelis Christos, Voineskos Aristotle, Dickie Erin, Temmingh Henk, Scheffler Freda, Gruber Oliver, Picotin Rosanne, Calhoun Vince D, Jensen Kyle M, Španiel Filip, Tomecek David, Salvador Raymond, Karuk Andriana, Salvador Raymond, Pomarol-Clotet Edith, Kircher Tilo, Teutenberg Lea, Stein Frederike, Dannlowski Udo, Grotegerd Dominik, Borgers Tiana, Hahn Tim, Lencer Rebekka, López-Jaramillo Carlos, Green Melissa, Quide Yann, Carr Vaughan, Ehrlich Stefan, Kochunov Peter, Sorg Christian, Thalhammer Melissa, Glahn David, Rodrigue Amanda, Sim Kang, Gonul Ali Saffet, Uyar Demir Aslihan, Crossley Nicolas, Gonzalez-Valderrama Alfonso, Homan Philipp, Omlor Wolfgang, Cecere Giacomo, Iasevoli Felice, Pontillo Giuseppe, Gur Raquel, Gur Ruben C, Ruparel Kosha, Satterthwaite Theodore D, Sponheim Scott, Demro Caroline, Chung Young Chul, Odkhuu Soyolsaikhan, Yang Albert, Chi I-Jou, Andreassen Ole, Westlye Lars T, Haukvik Unn K H, Parker Nadine, Kopal Jakub, Alnaes Dag, Rokicki Jaroslav, Sellgren Carl M, Lee Maria, Borgwardt Stefan, Avram Mihai, Lee Taeyoung, Jo Hang Joon, Lebedeva Irina, Tomyshev Alexander, Kaiser Stefan, Thompson Paul M, van Erp Theo G M, Turner Jessica A, Bernhardt Boris C, Valk Sofie L, Kirschner Matthias

Аннотация

Schizophrenia is often conceptualized as a brain network disorder, yet the organizational principles and heterogeneity underlying widespread cortical abnormalities remain poorly understood. Leveraging multisite MRI data from 3,958 individuals diagnosed with schizophrenia and 5,489 neurotypical individuals, we studied the cortical organization and its subtyping by analyzing individualized cortical network similarity. We used eigenvector decompositions to study spatial patterning of the gradients and graph theory to study small-world topology. Individuals with schizophrenia showed widespread alterations of gradient loadings, which followed inferior-superior and frontal-temporal axes. Alterations in small-world topology were localized in key network hubs, including the insula and anterior cingulate cortex. Brain-symptom association analyses identified a latent dimension linking disorganization symptoms to topological alterations. Finally, clustering cortical alterations identified two robust subtypes, characterized by divergent anterior cingulate (S1) versus temporoparietal (S2) thickness differences aligned with the intrinsic gradient-topology patterns. Both subtypes were present early in the illness and stable across disease stages and age groups. These findings reveal systematic disruptions of cortical organization in schizophrenia, providing a network-level framework for macroscale brain organization and inter-individual heterogeneity.

Individualized cortical gradient and network topology reveal symptom-linked disruptions and neurobiological subtypes in schizophrenia.

Ошибки и ограничения

Аннотация