Peripheral immune-vascular correlates of suicidal thoughts and behaviors in bipolar disorder and schizophrenia: cross-sectional and prospective analyses from the FACE-BD and FACE-SZ cohorts.
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Lengvenyte Aiste, Boukouaci Wahid, Wu Ching-Lien, Aouizerate Bruno, Bellivier Frank, Berna Fabrice, Capdevielle Delphine, Chereau Isabelle, Dondé Clément, Dubertet Caroline, Etain Bruno, Fakra Eric, Haffen Emmanuel, Januel Dominique, Korchia Theo, Lefrere Antoine, Llorca Pierre-Michel, Misdrahi David, Polosan Mircea, Rey Romain, Roux Paul, Samalin Ludovic, Schürhoff Franck, Schwan Raymund, Szekely David, Very Etienne, Walter Michel, Yrondi Antoine, Barau Caroline, Olié Emilie, Leboyer Marion, Courtet Philippe, FondaMental Advanced Centres of Expertise in Bipolar Disorders (FACE-BD) Collaborators, FondaMental Advanced Center of Expertise for Schizophrenia (FACE-SZ) collaborators
Аннотация
METHODS: We quantified 28 peripheral immune-vascular variables (cytokines/chemokines, vascular-injury markers, blood counts, lipids) in 980 French FACE (FondaMental Advanced Centres of Expertise) outpatients with BD (n = 529) or SZ (n = 451). Elastic-net logistic regression and partial least-squares regression for binary outcomes examined associations with SA, baseline SI, and SI over 12 months in pooled and diagnosis-stratified samples. Models adjusted for age, sex, and body mass index, with sensitivity analyses for depression severity, medication classes, smoking, phenotype overlap, attrition, and missing data.
RESULTS: In pooled analyses, SA was associated with higher vascular endothelial growth factor; stratified analyses suggested this signal was mainly driven by BD (OR = 1.33, 95% CI 1.08-1.64). In SZ, SA showed weaker platelet/SAA-related associations. Baseline SI showed more consistent multivariate signals than individual analytes; in BD, higher IL-7 and SAA remained associated with SI after adjustment, whereas SZ findings were more medication-sensitive. SI over 12 months showed the least stable associations; in BD, lower IL-7 was associated with follow-up SI (OR = 0.72, 95% CI 0.54-0.96). Internal validation indicated stronger performance for baseline SI than for SA or follow-up SI.
CONCLUSIONS: We found modest, phenotype-dependent and partly diagnosis-specific peripheral immune-vascular correlates of SI and SA in BD and SZ. Replication and direct biological validation are needed.