Nature · 2018

Improved reference genome of Aedes aegypti informs arbovirus vector control.

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди

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Matthews Benjamin J, Dudchenko Olga, Kingan Sarah B, Koren Sergey, Antoshechkin Igor, Crawford Jacob E, Glassford William J, Herre Margaret, Redmond Seth N, Rose Noah H, Weedall Gareth D, Wu Yang, Batra Sanjit S, Brito-Sierra Carlos A, Buckingham Steven D, Campbell Corey L, Chan Saki, Cox Eric, Evans Benjamin R, Fansiri Thanyalak, Filipović Igor, Fontaine Albin, Gloria-Soria Andrea, Hall Richard, Joardar Vinita S, Jones Andrew K, Kay Raissa G G, Kodali Vamsi K, Lee Joyce, Lycett Gareth J, Mitchell Sara N, Muehling Jill, Murphy Michael R, Omer Arina D, Partridge Frederick A, Peluso Paul, Aiden Aviva Presser, Ramasamy Vidya, Rašić Gordana, Roy Sourav, Saavedra-Rodriguez Karla, Sharan Shruti, Sharma Atashi, Smith Melissa Laird, Turner Joe, Weakley Allison M, Zhao Zhilei, Akbari Omar S, Black William C, Cao Han, Darby Alistair C, Hill Catherine A, Johnston J Spencer, Murphy Terence D, Raikhel Alexander S, Sattelle David B, Sharakhov Igor V, White Bradley J, Zhao Li, Aiden Erez Lieberman, Mann Richard S, Lambrechts Louis, Powell Jeffrey R, Sharakhova Maria V, Tu Zhijian, Robertson Hugh M, McBride Carolyn S, Hastie Alex R, Korlach Jonas, Neafsey Daniel E, Phillippy Adam M, Vosshall Leslie B

Аннотация

Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.

Improved reference genome of Aedes aegypti informs arbovirus vector control.

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