Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.
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Ошибки и ограничения
История · было → стало
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Nabulsi Leila, Kang Melody J Y, Jahanshad Neda, McPhilemy Genevieve, Martyn Fiona M, Haarman Bartholomeus, McDonald Colm, Hallahan Brian, O'Donoghue Stefani, Stein Dan J, Howells Fleur M, Scheffler Freda, Temmingh Henk S, Glahn David C, Rodrigue Amanda, Pomarol-Clotet Edith, Vieta Eduard, Radua Joaquim, Salvador Raymond, Karuk Andriana, Canales-Rodríguez Erick J, Houenou Josselin, Favre Pauline, Polosan Mircea, Pouchon Arnaud, Brambilla Paolo, Bellani Marcella, Mitchell Philip B, Roberts Gloria, Dannlowski Udo, Borgers Tiana, Meinert Susanne, Flinkenflügel Kira, Repple Jonathan, Leehr Elisabeth J, Grotegerd Dominik, Hahn Tim, Wessa Michèle, Phillips Mary L, Teutenberg Lea, Kircher Tilo, Straube Benjamin, Steinstraeter Olaf, Stein Frederike, Thomas-Odenthal Florian, Alexander Nina, Usemann Paula L, Jansen Andreas, Berk Michael, Dandash Orwa, Parker Nadine, Suo Chao, Thomopoulos Sophia I, Thompson Paul M, Andreassen Ole A, Ching Christopher R K, Cannon Dara M, ENIGMA Bipolar Disorder Working Group
Аннотация
METHODS: Cross-sectional structural and diffusion MRI scans from 449 individuals with BD (35.7±12.6 years) and 510 controls (33.3±12.6 years), aged 18-65, were analyzed across 16 ENIGMA-BD sites. Standardized segmentation/parcellation and constrained spherical deconvolution tractography generated individual structural connectivity matrices. Graph-theoretic metrics of global and subnetwork organization were related to symptom severity and medications.
RESULTS: BD showed widespread network alterations (lower density and efficiency, longer path length, and higher betweenness centrality), altered microstructural organization in a limbic-basal ganglia circuit, and abnormal streamline counts in a default-mode/salience/fronto-limbic-basal ganglia network. Longer illness duration, later onset, and psychosis history were associated with greater abnormalities in network architecture, whereas more manic episodes were associated with greater fronto-limbic connectivity. Antidepressant (particularly SSRI), anticonvulsant, and antipsychotic use related to poorer global and fronto-limbic connectivity; no clear lithium effects emerged.
CONCLUSIONS: As the largest structural connectivity study in BD, we reveal widespread disruption in reward and emotion-regulation networks influenced by illness severity and medication use. Results show that multisite harmonization is feasible and highlight ENIGMA-BD as a scalable framework for identifying reproducible neurobiological markers.