Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026
Theta-cordance as a biomarker of treatment response to intermittent theta burst stimulation in patients with treatment-resistant depression.
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Reissmann Andreas, Rupprecht Maximilian, Langguth Berthold, Rischer Johanna, Schoisswohl Stefan
Аннотация
OBJECTIVE: To test whether baseline or treatment-related changes in prefrontal theta cordance are associated with clinical outcome after intermittent theta burst stimulation (iTBS) for major depressive disorder (MDD).
METHODS: Retrospective analysis of 30 inpatients receiving 10 sessions of left-sided iTBS over 2 weeks. Resting-state 19-channel EEG was processed to compute theta cordance (plus delta/alpha/beta) in predefined cortical clusters pre/post the iTBS treatment period. Depression was rated pre/post with the Hamilton Depression Rating Scale (HAM-D) and the Major Depression Inventory (MDI); correlations linked baseline values and change scores to symptom improvement.
RESULTS: Baseline prefrontal theta cordance was not associated with outcome. Change scores were region-specific: responders showed greater occipital decreases (OC p = 0.036; MLOC p = 0.009) and a trend toward left-frontal increases (MLFC p = 0.072); exploratory alpha and delta effects also emerged.
CONCLUSIONS: Theta cordance may predict and track symptom improvement following iTBS, indicating state-dependent neurophysiology.
SIGNIFICANCE: Theta cordance may serve as a dynamic, region-specific EEG marker to monitor and personalize iTBS; prospective validation is warranted.
METHODS: Retrospective analysis of 30 inpatients receiving 10 sessions of left-sided iTBS over 2 weeks. Resting-state 19-channel EEG was processed to compute theta cordance (plus delta/alpha/beta) in predefined cortical clusters pre/post the iTBS treatment period. Depression was rated pre/post with the Hamilton Depression Rating Scale (HAM-D) and the Major Depression Inventory (MDI); correlations linked baseline values and change scores to symptom improvement.
RESULTS: Baseline prefrontal theta cordance was not associated with outcome. Change scores were region-specific: responders showed greater occipital decreases (OC p = 0.036; MLOC p = 0.009) and a trend toward left-frontal increases (MLFC p = 0.072); exploratory alpha and delta effects also emerged.
CONCLUSIONS: Theta cordance may predict and track symptom improvement following iTBS, indicating state-dependent neurophysiology.
SIGNIFICANCE: Theta cordance may serve as a dynamic, region-specific EEG marker to monitor and personalize iTBS; prospective validation is warranted.