The Link Between Weight Gain and Hippocampal Atrophy in Bipolar Disorder: A Longitudinal Investigation in 934 Participants.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fraiha-Pegado Julia, McWhinney Sean R, Alda Martin, Alexander Nina, Anmella Gerard, Abé Christoph, Altegoer Luisa, Benedetti Francesco H, Berk Michael, Bøen Erland, Bond David J, Boye Brigitte, Bravi Beatrice, Cannon Dara M, Corkum Emily L V, Corley Emma, Dietze Lorielle M F, Dannlowski Udo, Elvsåshagen Torbjorn, Fuentes-Claramonte Paola, Fullerton Janice M, Goldstein Benjamin I, Goltermann Janik, Grotegerd Dominik, Hahn Tim, Hidalgo-Mazzei Diego, Im Yanghee, Kang Melody, Karuk Andriana, Kennedy Kody G, Kircher Tilo, Klahn Anna Luisa, Kraus Anna, Landén Mikael, Leehr Elisabeth J, Machado-Vieira Rodrigo, MacIntosh Bradley J, Malt Ulrik F, Mazza Elena, McDonald Colm, Meinert Susanne, Melloni Elisa, Mitchell Phillip B, Nabulsi Leila, Nitsch Robert, O'Connor John, Opel Nils, Otaduy Maria C G, Overs Brownyn J, Parker Nadine, Poletti Sara, Pomarol-Clotet Edith, Radua Joaquim, Roberts Gloria, Salvador Raymond, Suo Chao, Schofield Peter R, Selitser Maya, Sim Kang, Straube Benjamin, Teutenberg Lea, Thomopoulos Sophia I, Usemann Paula, Vieta Eduard, Westlye Lars T, Wu Linzhi, Yatham Lakshmi N, Thompson Paul M, Andreassen Ole A, Ching Christopher R K, Hajek Tomas, ENIGMA Bipolar Disorder and BMIx Working Groups
Аннотация
METHODS: In collaboration with the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis)-BD Working Group, we obtained T1-weighted magnetic resonance imaging and clinical data from 233 participants with BD and 701 healthy control participants (HCs) scanned twice, 2.84 ± 1.63 years apart on average. We estimated subcortical volumes using FreeSurfer longitudinal image processing stream and used linear mixed models to assess the bidirectional relationship between baseline body mass index (BMI) or BMI change and hippocampal volume or volume change. While the hippocampus was our a priori region of interest, we repeated these analyses in other subcortical regions.
RESULTS: Baseline BMI predicted future hippocampal atrophy, but baseline brain structure did not predict future weight changes. BMI increased significantly over time (F1,1085 = 15.98, p < .001). Individuals with lower baseline BMI experienced greater weight gain (F1,922 = 105.12, p < .001). Greater weight gain was associated with greater hippocampal atrophy over time (F1,899 = 16.33, p = .001), more so in participants with BD than HCs (F1,898 = 6.91, p = .009). Consequently, lower baseline BMI predicted greater future hippocampal volume loss (F1,904 = 14.77, p < .001). These associations were not observed in other subcortical regions.
CONCLUSIONS: Our findings suggest that weight gain is a modifiable risk factor for hippocampal atrophy, especially in individuals with lower BMI and those with BD. Prevention of weight gain in general, but especially in people with BD, could provide neuroprotective benefits.