Lower Gyrification of the Ventromedial Prefrontal Cortex in Posttraumatic Stress Disorder: An ENIGMA-PTSD Study.
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Hussain Ahmed, Baird C Lexi, Huggins Ashley A, Russell Courtney C, Sun Delin, Rangel-Jimenez Leonel, Abdallah Chadi G, Angstadt Michael, May Geoffrey, Berg Hannah, Blackford Jennifer U, Cisler Josh, Daniels Judith K, Davenport Nicholas D, Davidson Richard J, Densmore Maria, Disner Seth G, El-Hage Wissam, Etkin Amit, Fani Negar, Frijling Jessie L, Gordon Evan M, Grupe Daniel W, Herringa Ryan A, Herzog Julia I, Hofmann David, Hudson Anna R, Jovanovic Tanja, King Anthony, Koch Saskia B J, Lanius Ruth A, Lazarov Amit, Li Gen, Liberzon Israel, Lissek Shmuel, Lu Guangming, Manthey Antje, Maron-Katz Adi, McLaughlin Katie A, Mueller Sven C, Nawijn Laura, Nelson Steven M, Neria Yuval, Neufeld Richard W J, Nitschke Jack B, Olatunji Bunmi O, Olff Miranda, Peverill Matthew, Qi Rongfeng, Quidé Yann, Ravid Orren, Rektor Ivan, Ressler Kerry J, Říha Pavel, Ross Marisa, Sambrook Kelly, Schmahl Christian, Sierk Anika, Sponheim Scott R, Stevens Jennifer S, Straube Thomas, Suarez-Jimenez Benjamin, Théberge Jean, van der Wee Nic J A, van der Werff Steven J A, van Rooij Sanne J H, van Zuiden Mirjam, Veltman Dick J, Vermeiren Robert R J M, Walter Henrik, Wang Li, Zhu Xi, Zhu Ye, Zilcha-Mano Sigal, Jahanshad Neda, Thompson Paul M, Morey Rajendra A
Аннотация
METHODS: Gyrification was quantified using FreeSurfer's Local Gyrification Index (lGI), derived from 3-dimensional T1-weighted volumetric brain magnetic resonance imaging in 1876 participants (PTSD n = 789, control n = 1087) across 24 sites from the ENIGMA-PGC (Enhancing Neuro Imaging Genetics through Meta-Analysis and Psychiatric Genomics Consortium) PTSD working group. Using a region of interest-based approach, we fitted a linear mixed-effects model with age (mean = 35.6, SD = 9.23, range = 8-95), sex (female = 967 [52%], male = 909 [48%]), pial surface area, PTSD, and random site effects to test associations between PTSD diagnosis/severity and regional lGI. We examined moderating effects of depression, childhood trauma, age, and sex.
RESULTS: PTSD diagnosis and severity were both associated with lower lGI for the right medial orbitofrontal and right rostral anterior cingulate cortices. The interaction of PTSD and age was associated with lower lGI for the rostral middle frontal cortex bilaterally. Contrasting comorbid PTSD and major depressive disorder with the PTSD-only group showed that comorbidity was associated with lower lGI in the left inferior and medial temporal cortices.
CONCLUSIONS: Lower lGI, which is associated with impaired signaling efficiency, was observed in the PTSD group compared with the control group for the ventromedial prefrontal cortex, a region that has been strongly implicated in associative fear learning and extinction. It is possible that PTSD accelerates the typical age-associated decline in lGI of the rostral middle frontal cortices.