Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
T-cell depletion and oral candidiasis in Kyasanur Forest disease: a case series.
СтатьяКлинический случайПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Gupta Nitin, Kiran Pothumarthy Venkata Swathi, Sebastian Anjely, Varma Muralidhar, Kumar Tirlangi Praveen
Аннотация
BACKGROUND: Kyasanur Forest Disease (KFD) is a tick-borne viral haemorrhagic fever endemic to southern India.
METHODS: We present a case series of five PCR-confirmed patients with KFD who developed oral candidiasis. CD4 and CD8 T-lymphocyte counts were measured using flow cytometry alongside detailed clinical assessment.
RESULTS: All five patients with candidiasis had CD4 counts <300 cells/µl, and four had CD8 counts <200 cells/µl. None had other known immunosuppressive conditions.
CONCLUSION: CD4 and CD8 lymphopenia are consistent and clinically relevant features among patients with KFD who developed oral candidiasis, suggesting transient mucosal immune suppression as a potential pathogenic mechanism.
METHODS: We present a case series of five PCR-confirmed patients with KFD who developed oral candidiasis. CD4 and CD8 T-lymphocyte counts were measured using flow cytometry alongside detailed clinical assessment.
RESULTS: All five patients with candidiasis had CD4 counts <300 cells/µl, and four had CD8 counts <200 cells/µl. None had other known immunosuppressive conditions.
CONCLUSION: CD4 and CD8 lymphopenia are consistent and clinically relevant features among patients with KFD who developed oral candidiasis, suggesting transient mucosal immune suppression as a potential pathogenic mechanism.