Case Series of Patients With Laboratory-Confirmed Marburg Virus Disease in 2023 in Equatorial Guinea.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Ondo Ndoho Florentino Abaga, Fontana Luca, Ondo Avomo Candido Ondo, Mikue Ladislao Ekiri Ngomo, Fuga Eyemam Domitila Ñadang, Nguere Micaela Ayang, Mometolo Ilda Elobe, Bibang Nzang Rosalia Nazang, Nguema Maye Damaso Mitogo, Hernandez Suarez Yosbanis, Esono Salvador Eduardo, Miko Ayang José Antonio, Giuliani Ruggero, Jacquerioz Frédérique, Lang Hans-Joerg, Kojan Richard, Chaillon Antoine, Ngai Stephanie, de Waroux Olivier le Polain, Silenzi Anna, Di Marco Michele, Legand Anaïs, Formenty Pierre, Negron Maria E, Klena John D, Choi Mary J, Mayer Oren, Scholte Florine E M, Welch Stephen R, Gutierrez Emily Zielinski, Diaz Janet
Аннотация
METHODS: Patients with confirmed MVD who were admitted to the national treatment center in Bata, Equatorial Guinea were monitored for vital signs and symptoms. Comprehensive clinical data were collected to understand the progression and outcome of the disease.
RESULTS: Five patients were confirmed to have MVD. Three male healthcare workers received a diagnosis diagnosed early in their disease and subsequently survived. The other 2 patients, both female, were admitted later in their disease progression and died within 24 hours of admission. Four patients received remdesivir under a protocol for the monitored emergency use of unregistered and experimental interventions. The early symptoms were nonspecific, with rapid progression to more severe conditions in the later stages of the disease. Early treatment with remdesivir showed the drug to be well tolerated.
CONCLUSIONS: Contrary to some reports and the recommended case definition for MVD, our patients presented with a rash but did not exhibit vomiting or diarrhea. Hemorrhagic signs were solely observed in the terminal stage, preceding demise. Despite the limited sample size, these findings emphasize the importance of tailoring the case definition to the specific outbreak. Further evidence on the efficacy and safety of therapeutics for MVD, including remdesivir, should be gathered through well-designed trials during future epidemic responses.