Therapeutic advances in endocrinology and metabolism · 2025
Role of vitamin D in the development and progression of diabetic kidney disease: an overview of meta-analyses.
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Chackochan Ashna, Rashid Muhammed, Reghunath Swetha R, Poojari Pooja Gopal, Thunga Girish, Nagri Shivashankara Kaniyoor, Guddattu Vasudeva, Shenoy Revathi P, Prasad Shenoy Vishnu, Acharya Leelavathi D
Аннотация
BACKGROUND: The effectiveness of vitamin D supplementation in the progression of diabetic kidney disease (DKD) remains controversial. Our review tries to provide a comprehensive summary of all the relevant articles in the area to assess the association of vitamin D deficiency with the development of DKD and the effect of vitamin D supplementation on the progression of DKD.
METHODS: PubMed, Embase, Scopus, Cochrane Library and Web of Science were accessed from inception till June 2024 to obtain all the relevant meta-analyses assessing the function of vitamin D in the onset and prognosis of DKD. The summary data were extracted by two independent reviewers. A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 tool was used for the assessment of the methodological quality of the included meta-analyses.
RESULTS: A total of 4579 articles were obtained from 5 databases in the initial search, of which 8 meta-analyses were included for the evidence synthesis. The methodological quality of the retrieved articles ranged from critically low to high. Serum vitamin D levels were significantly correlated with the prevalence of DKD. The review suggested that vitamin D supplementation could help in reducing proteinuria. However, no such changes were observed in other renal function parameters of DKD patients following vitamin D supplementation.
CONCLUSION: The current evidence indicates that vitamin D supplementation could be beneficial in reducing proteinuria among DKD patients.PROSPERO registration number: CRD42022375194.
METHODS: PubMed, Embase, Scopus, Cochrane Library and Web of Science were accessed from inception till June 2024 to obtain all the relevant meta-analyses assessing the function of vitamin D in the onset and prognosis of DKD. The summary data were extracted by two independent reviewers. A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2 tool was used for the assessment of the methodological quality of the included meta-analyses.
RESULTS: A total of 4579 articles were obtained from 5 databases in the initial search, of which 8 meta-analyses were included for the evidence synthesis. The methodological quality of the retrieved articles ranged from critically low to high. Serum vitamin D levels were significantly correlated with the prevalence of DKD. The review suggested that vitamin D supplementation could help in reducing proteinuria. However, no such changes were observed in other renal function parameters of DKD patients following vitamin D supplementation.
CONCLUSION: The current evidence indicates that vitamin D supplementation could be beneficial in reducing proteinuria among DKD patients.PROSPERO registration number: CRD42022375194.