[Low-affinity Fcγ receptor IIa gene polymorphism and dengue bleeding disorder].

INTRODUCTION

The pathophysiological changes that determine the severity of dengue are still not well known, therefore it is important to study the probable relationship with the host genetic.

METHODS

We analyzed the possible association between the FcγRIIa polymorphism and clinical signs in individuals who suffered dengue infection in 2006, using contingency tables.

RESULTS

We found that bleeding was significantly associated to FcγRIIa H/H131 genotype (80%).

CONCLUSION

Our results suggest that in clinical dengue infection the bleeding could be associated to FcγRIIa H/H131 genotype.