The effects of novelty and behavioral stereotype on the development of amnesia in mice.

The aim of the present study was to analyze the significance of the interaction between the basic behavioral strategy, the extinction of the novelty of information, and the efficacy of amnesia-inducing influences. Using a combination of training to passive avoidance with holding the animal in the unsafe sector of the apparatus, comparative analysis was performed of the reproduction of a memory trace in aggressive and submissive mice of line C57BL/6J with and without six sessions of familiarization with the apparatus. These experiments showed that preliminary habituation prevented the development of amnesia in submissive but not aggressive individuals. The cause of these differences in the effects of preexposure on the development of amnesia involves the selectivity of the process of extinction of information novelty characteristic for the behavioral stereotype.