Psychopharmacology · 2003
Increased temporal patterns in choice responding and altered cognitive processes in schizophrenia and mania.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Lyon Melvin, Kemp Aaron S
Аннотация
RATIONALE: The THEME method for measuring time-determined patterns (T-patterns) in behavior has been suggested as a new, more objective method for assessing cognitive disturbances in schizophrenia.
OBJECTIVES: THEME was used to compare responses of schizophrenic patients with those having mood, schizoaffective, or severe anxiety disorders, and with healthy control subjects.
METHODS: A two-choice, button-pressing task was used to elicit T-patterns among responses, with knowledge-of-results (K) rewards and coin reinforcements (RF) as reinforcers. Subjects were compared by diagnosis, drug treatment, and gender.
RESULTS: Schizophrenic and manic patients showed excessive numbers of, and more complex T-patterns than controls. Schizophrenic and manic patients frequently demonstrated repetitive (stereotyped) responding, an effect never seen in healthy controls. Although clozapine (CLZ) reduced both excessive T-pattern structure and stereotyped responding, it also reduced growth of responding to the coin RF.
CONCLUSIONS: Significant T-pattern increases may represent a common, time-related symptom of schizophrenia and mania. CLZ's effect on T-pattern production suggests that receptor effects other than the DAD(2) antagonism of "typical" neuroleptics' may be relevant to these findings.
OBJECTIVES: THEME was used to compare responses of schizophrenic patients with those having mood, schizoaffective, or severe anxiety disorders, and with healthy control subjects.
METHODS: A two-choice, button-pressing task was used to elicit T-patterns among responses, with knowledge-of-results (K) rewards and coin reinforcements (RF) as reinforcers. Subjects were compared by diagnosis, drug treatment, and gender.
RESULTS: Schizophrenic and manic patients showed excessive numbers of, and more complex T-patterns than controls. Schizophrenic and manic patients frequently demonstrated repetitive (stereotyped) responding, an effect never seen in healthy controls. Although clozapine (CLZ) reduced both excessive T-pattern structure and stereotyped responding, it also reduced growth of responding to the coin RF.
CONCLUSIONS: Significant T-pattern increases may represent a common, time-related symptom of schizophrenia and mania. CLZ's effect on T-pattern production suggests that receptor effects other than the DAD(2) antagonism of "typical" neuroleptics' may be relevant to these findings.