Neuroscience research · 2002
Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Mori Atsushi, Okuyama Keiji, Horie Masato, Taniguchi Yoshihiro, Wadatsu Takashi, Nishino Naoki, Shimada Yoshikazu, Miyazawa Norihiro, Takeda Satoshi, Niimi Masashi, Kyushiki Hiroyuki, Kondo Mari, Mitsumoto Yasuhide
Аннотация
Mint-1, which is also called as X11 or mammalian Lin10, protein has been implicated in the synaptic vesicle exocytosis and the targeting and localization of synaptic membrane proteins. Here, we established mint-1 gene knockout (mint-1 KO) mice and investigated vesicular and transporter-mediated dopamine (DA) release evoked by high K(+) and methamphetamine (METH), respectively. Compared with wild-type control, high K(+)-evoked striatal DA release was attenuated, but not significantly, in the KO mice as measured by microdialysis method. The METH-induced DA release was significantly attenuated in the KO mice. In addition, METH-induced stereotypy was also significantly attenuated in the KO mice. Mint-1 KO mice showed more sensitive and prominent behavioral response to an approaching object as compared with wild-type mice. These results suggest that mint-1 protein is involved in transporter-mediated DA release induced by METH.