A combination of laser-assisted ALA-PDT for squamous cell carcinoma in situ and field-directed ALA-PDT for actinic keratosis.

Actinic keratosis (AK) is a chronic and recurrent disease caused by long-term sun exposure. Grade 3 AK is considered early squamous cell carcinoma in situ (SCCis). Field- and lesion-directed therapeutic approaches can improve the efficacy and reduce treatment time and cost. It is particularly suitable for AK patients with lesions of differing grades. Herein, we present a case of multiple AK lesions with local SCCis on the face. This patient achieved complete remission after one session of CO2 laser and three sessions of 5-Aminolevulinic acid photodynamic therapy (ALA-PDT). There was no recurrence as of 1 year into follow-up.