Медицинская библиотека · Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019

Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience.

Lloret M, García-Cabrera L, Hernandez A, Santana N, López-Molina L, Lara P C

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Аннотация

BACKGROUND

Hyperthermia (HT) is used to increase the temperature of the tumor-sensitizing cells to the effects of radiation/chemotherapy. We aimed to assess the feasibility, tolerability and safety of hyperthermia treatment in a Radiation Oncology Department.

METHODS

Between June 2015 and June 2017, 106 patients and a total of 159 tumor lesions were included in a prospective study (EudraCT 2018-001089-40) of HT concomitant with radiotherapy (RT). Systemic treatment was accepted. HT was given twice a week, 60 min per session, during RT treatment by a regional capacitive device (HY-DEEP 600WM system) at 13.56 MHz radiofrequency.

RESULTS

Most lesions (138 cases, 86.8%) received all HT sessions planned. Thirteen lesions (12 patients) withdrew treatment due to grade ≥3 QMHT toxicity. All these 12 patients completed the prescribed radiotherapy and/or systemic treatment.

CONCLUSIONS

Regional hyperthermia is a feasible and safe technique to be used in combination with radiotherapy and systemic treatment.

Для цитирования: Lloret M, García-Cabrera L, Hernandez A, Santana N, López-Molina L, Lara P C. Feasibility of a deep hyperthermia and radiotherapy programme for advanced tumors: first Spanish experience.. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2019. DOI: 10.1007/s12094-019-02097-9.

Предметные рубрики MeSH

Adult Aged Aged, 80 and over Combined Modality Therapy Feasibility Studies Female Humans Hyperthermia, Induced Male Middle Aged Neoplasms Prospective Studies Radiotherapy

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