Behavioral effects of N-cyanomethylmethamphetamine, a product derived from smoking methamphetamine with tobacco, in mice and rats.

The stimulant effects of N-cyanomethylmethamphetamine (CMMA), a product derived from smoking methamphetamine (MA) mixed in tobacco, were studied by observing stereotyped behavior and measuring spontaneous motor activity in mice and rats over 180 min CMMA. 1.3 and 10 mg/kg IP, elicited strong stimulant-like effects which were almost equivalent to those produced by MA. Drug monitoring for 180 min in mouse and rat plasma revealed that the principal substances responsible for the stimulant effect of CMMA were MA and amphetamine (AP) which were metabolized from CMMA by the animal. There was a species difference in metabolism of CMMA between mice and rats. The major metabolites were MA and AP in mouse plasma, followed by N-formylmethamphetamine (FMA), whereas the major metabolite was FMA in rat plasma, followed by MA and AP. The differences in the stimulant effects of CMMA between mice and rats were discussed in relation to its metabolic fate in mice and rats.