Case Report: Albumin combined with plasma exchange in the treatment of refractory thrombotic thrombocytopenic purpura.

OBJECTIVE

This study aims to analyze the clinical characteristics and causes of misdiagnosis in patients with thrombotic thrombocytopenic purpura (TTP) presenting with initial neurological symptoms, so as to provide reference for reducing misdiagnosis; to explore the feasibility and efficacy of albumin combined with plasma exchange in the treatment of TTP patients when plasma inventory is insufficient; and to put forward key precautions for TTP diagnosis and treatment, so as to provide strategic support for the treatment of similar cases.

METHODS

Clinical data of the patient (medical history, examination results, diagnosis and treatment records, etc.) were collected retrospectively; albumin combined with plasma exchange was adopted when plasma inventory was insufficient; laboratory indicators and symptom recovery were dynamically monitored to evaluate the effectiveness and safety of the treatment; misdiagnosis risks and the current status of alternative treatment were analyzed combined with literature review.

CONCLUSION

Thrombotic thrombocytopenic purpura with initial neurological symptoms is easily confused with cerebral infarction, and thrombocytopenia of unknown origin is a key clue for differential screening. TTP should be excluded before platelet transfusion; when plasma inventory is insufficient, albumin combined with plasma exchange is feasible and effective for the treatment of AB-blood-type TTP, which can provide an alternative strategy for clinical practice; early diagnosis, timely targeted treatment and multidisciplinary collaboration are the keys to improving the prognosis of TTP patients.