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Войти в исследования Laboratory medicine · 2026
ABO discrepancies revealing rare weak A subgroups: a 2-case series.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Marchini Ande, Onyenekwu Chinelo, Ruegsegger Patricia, Fuja Christine, Rose William, Raymond Caitlin
Аннотация
INTRODUCTION: ABO discrepancies caused by weak A subgroups are uncommon but clinically important because they can lead to mistyping and inappropriate transfusion management.
METHODS: We present the cases of 2 patients at an academic medical center who were historically typed as group O but were found to harbor weak A subgroups upon detailed investigation.
RESULTS: In case 1, the patient's red blood cells demonstrated weak reactivity with anti-A reagent on forward typing, with anti-A1 and anti-B identified on reverse typing. In case 2, the patient's red blood cells were nonreactive with anti-A reagent on forward typing but did agglutinate with anti-A,B reagent. Reverse typing showed weak reactivity against A1 and A2 cells, with strong reactivity against B cells, consistent with an anti-A antibody. In both cases, molecular genotyping performed at a reference laboratory returned results consistent with an Aw or Ael allele.
DISCUSSION: These cases illustrate the serologic spectrum of weak A phenotypes, highlight the variable sensitivity of ABO reagents in detecting minimal antigen expression, and underscore the possible utility of molecular characterization when serologic results are ambiguous.
METHODS: We present the cases of 2 patients at an academic medical center who were historically typed as group O but were found to harbor weak A subgroups upon detailed investigation.
RESULTS: In case 1, the patient's red blood cells demonstrated weak reactivity with anti-A reagent on forward typing, with anti-A1 and anti-B identified on reverse typing. In case 2, the patient's red blood cells were nonreactive with anti-A reagent on forward typing but did agglutinate with anti-A,B reagent. Reverse typing showed weak reactivity against A1 and A2 cells, with strong reactivity against B cells, consistent with an anti-A antibody. In both cases, molecular genotyping performed at a reference laboratory returned results consistent with an Aw or Ael allele.
DISCUSSION: These cases illustrate the serologic spectrum of weak A phenotypes, highlight the variable sensitivity of ABO reagents in detecting minimal antigen expression, and underscore the possible utility of molecular characterization when serologic results are ambiguous.