Localization of transient receptor potential channel vanilloid subfamilies in the mouse larynx.

CONCLUSION

Laryngeal epithelium contains TRPV1, 2, 3 and 4, which may act as laryngeal nociceptors perceiving luminal noxious stimuli, play an important role in thermal sensation, osmotic sensation, and are also related to pathological conditions, such as inflammatory response, genesis of cough, asthma.

OBJECTIVE

Expression of TRPV1, 2, 3 and 4 in the normal CBA/J mouse larynx was analysed.

MATERIALS AND

METHODS

CBA/J mice were used in this study. The localizations of TRPV1, 2, 3 and 4 in the laryngeal epithelium were investigated by immunohistochemistry.

RESULTS

Immunohistochemical study revealed the presence of TRPV1, 2, 3 and 4 in the laryngeal epithelial cells. TRPV1 and TRPV2 were often co-localized with substance P, while the co-localization of substance P and TRPV3 was rare and TRPV4 was not co-localized with substance P.