A novel and integrated software solution for providing compatible platelets to HLA-sensitized patients.

Transfusion support for sensitized patients is an important function of blood centers and HLA laboratories. However, access to widely available software to facilitate matching patients with compatible donor units is limited. We developed vendor-supported and integrated software that interfaces with the laboratory informatics system, sourcing typing data from our platelet donor registry and retrieving patient HLA typing and unacceptable antibody specificities. The application filters antigen-negative donors and ranks them using an algorithm that incorporates HLA match, donor homozygosity, and cross-reactive group comparison for mismatched antigens, and generates a customizable report of ranked donors for the blood center. Low, moderate, and high antibody reactivities can be filtered to better support highly sensitized patients. Implementing vendor-supported software ensures continued maintenance, support, and the opportunity for updates with evolving platelet matching protocols. This customizable solution reduces transcription errors and streamlines data retrieval, allowing provision of timely and efficient transfusion support for patients.