Saudi journal of biological sciences · 2021
Factor XII deficiency in asymptomatic Saudi population: A retrospective cohort study.
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Alqahtany Fatmah S, Algahtani Farjah H, Alshebly Mashael M, Albegamy Thamer S, Alghamdi Essam S, Alnakhli Mohammed A, Madkhaly Fatimah M, Alharbi Abdullah A, Alqahtani Nawaf A
Аннотация
Factor XII (FXII) deficiency is a rare genetic blood disorder. It can lead to a higher risk of developing deep vein thrombosis or acquired thrombotic disorders than the general population. This retrospective study evaluated patients who opted for surgery and were found to have abnormal clotting profiles and clotting factors on preoperative routine blood. Patients were included regardless of whether they were symptomatic or asymptomatic. The cohort comprised 115 patients with a mean FXII level of 128.04 ± 36.93%. Two (1.79%) patients, both of whom were women, had FXII levels <60%. The mean FXII level was 58 ± 1.41 (range, 57-59%) in this group. The present study shows the prevalence of FXII in the asymptomatic Saudi population. The results provide the normal range for FXII. The findings of our study provide the basis for diagnosing F XII deficiency in the asymptomatic Saudi population.