Clinical laboratory · 2019
The Hemostatic Conundrum of Thrombotic Thrombocytopenic Purpura: a Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Pillay Evashin, Louw Susan
Аннотация
BACKGROUND: In thrombotic thrombocytopenic purpura (TTP), von Willebrand factor (VWF)-platelet rich thrombi form in the microvasculature with ischemia in vital organs. The pathogenesis relates to deficiency of the VWF cleaving protease, ADAMTS-13.
METHODS: A case study of a 58-year-old female with previously undiagnosed HIV (human immunodeficiency virus) infection, left hemiparesis, and soft tissue hemorrhages.
RESULTS: Investigations revealed microangiopathic hemolytic anemia and a left basal ganglia infarct on magnetic resonance imaging (MRI). A diagnosis of acquired, HIV-related TTP was made and therapeutic plasma exchange and antiretroviral therapy were initiated.
CONCLUSIONS: The combined thrombotic and hemorrhagic manifestations of TTP pose therapeutic challenges.
METHODS: A case study of a 58-year-old female with previously undiagnosed HIV (human immunodeficiency virus) infection, left hemiparesis, and soft tissue hemorrhages.
RESULTS: Investigations revealed microangiopathic hemolytic anemia and a left basal ganglia infarct on magnetic resonance imaging (MRI). A diagnosis of acquired, HIV-related TTP was made and therapeutic plasma exchange and antiretroviral therapy were initiated.
CONCLUSIONS: The combined thrombotic and hemorrhagic manifestations of TTP pose therapeutic challenges.