AgBF4-catalyzed insertion of unactivated alkynes into C-F bonds of acyl fluorides.

We report an AgBF4-catalyzed intermolecular C-F insertion of unactivated alkynes into acyl fluorides, providing a general route to monofluoroalkenes. This transformation enables both C-F bond cleavage and reformation without activated coupling partners, driven by cooperative Ag+/BF4 - catalysis, where BF4 - functions as a fluoride shuttle. The reaction exhibits broad substrate scope, accommodating aromatic and aliphatic acyl fluorides with high Z-selectivity. Given that monofluoroalkenes are valuable amide bioisosteres, this method enables direct access to bio-relevant motifs from carboxylic acid derivatives and supports late-stage monofluoroalkene installation in complex molecules.