British journal of cancer · 2026
The ALLAN trial: impact of early home-based palliative care on emergency care and hospitalisation in advanced gastrointestinal cancer patients.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод в очереди
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Bojesson A, Brun E, Eberhard J, Segerlantz M
Аннотация
BACKGROUND: Patients with advanced gastrointestinal (GI) cancer experience a high symptom burden which frequently necessitates emergency care. Integration of early home-based specialised palliative care (SPC) with tumour-specific treatments may impact emergency healthcare use.
METHODS: At the initiation of palliative chemotherapy, patients with advanced GI cancer were randomised to early home-based SPC integrated with tumour-specific treatment, or tumour-specific treatment with SPC referral when needed. The aim was to compare quality of life in the two groups. Here we present secondary outcomes; number of emergency department visits, hospitalisations, days of inpatient care, the time from the last chemotherapy treatment to death, and the place of death between the study groups.
RESULTS: A total of 118 patients were randomised. Patients in the early SPC group had significantly fewer emergency department visits (median 1 versus 3), hospitalisations (median 1 versus 2), and inpatient care days (median 1.5 vs. 11.5) compared to the control group (p < 0.001). There was no significant difference between the study groups in either time between the last chemotherapy treatment and death, inpatient SPC or place of death.
CONCLUSION: Early integration of home-based SPC in advanced GI cancer patients significantly reduces emergency healthcare use and hospitalisation.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (ref: NCT02246725).
METHODS: At the initiation of palliative chemotherapy, patients with advanced GI cancer were randomised to early home-based SPC integrated with tumour-specific treatment, or tumour-specific treatment with SPC referral when needed. The aim was to compare quality of life in the two groups. Here we present secondary outcomes; number of emergency department visits, hospitalisations, days of inpatient care, the time from the last chemotherapy treatment to death, and the place of death between the study groups.
RESULTS: A total of 118 patients were randomised. Patients in the early SPC group had significantly fewer emergency department visits (median 1 versus 3), hospitalisations (median 1 versus 2), and inpatient care days (median 1.5 vs. 11.5) compared to the control group (p < 0.001). There was no significant difference between the study groups in either time between the last chemotherapy treatment and death, inpatient SPC or place of death.
CONCLUSION: Early integration of home-based SPC in advanced GI cancer patients significantly reduces emergency healthcare use and hospitalisation.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov (ref: NCT02246725).