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DOI 10.1038/s41586-021-03901-9

Медицинская библиотека · Nature · 2021

Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks.

Keita Alpha Kabinet, Koundouno Fara R, Faye Martin, Düx Ariane, Hinzmann Julia, Diallo Haby, Ayouba Ahidjo, Le Marcis Frederic, Soropogui Barré, Ifono Kékoura, Diagne Moussa M, Sow Mamadou S, Bore Joseph A, Calvignac-Spencer Sebastien, Vidal Nicole, Camara Jacob, Keita Mamadou B, Renevey Annick, Diallo Amadou, Soumah Abdoul K, Millimono Saa L, Mari-Saez Almudena, Diop Mamadou, Doré Ahmadou, Soumah Fodé Y, Kourouma Kaka, Vielle Nathalie J, Loucoubar Cheikh, Camara Ibrahima, Kourouma Karifa, Annibaldis Giuditta, Bah Assaïtou, Thielebein Anke, Pahlmann Meike, Pullan Steven T, Carroll Miles W, Quick Joshua, Formenty Pierre, Legand Anais, Pietro Karla, Wiley Michael R, Tordo Noel, Peyrefitte Christophe, McCrone John T, Rambaut Andrew, Sidibé Youssouf, Barry Mamadou D, Kourouma Madeleine, Saouromou Cé D, Condé Mamadou, Baldé Moussa, Povogui Moriba, Keita Sakoba, Diakite Mandiou, Bah Mamadou S, Sidibe Amadou, Diakite Dembo, Sako Fodé B, Traore Fodé A, Ki-Zerbo Georges A, Lemey Philippe, Günther Stephan, Kafetzopoulou Liana E, Sall Amadou A, Delaporte Eric, Duraffour Sophie, Faye Ousmane, Leendertz Fabian H, Peeters Martine, Toure Abdoulaye, Magassouba N' Faly

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak-between 14 February and 19 June 2021-near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.

Для цитирования: Keita Alpha Kabinet, Koundouno Fara R, Faye Martin, Düx Ariane, Hinzmann Julia, Diallo Haby, Ayouba Ahidjo, Le Marcis Frederic, Soropogui Barré, Ifono Kékoura, Diagne Moussa M, Sow Mamadou S, Bore Joseph A, Calvignac-Spencer Sebastien, Vidal Nicole, Camara Jacob, Keita Mamadou B, Renevey Annick, Diallo Amadou, Soumah Abdoul K, Millimono Saa L, Mari-Saez Almudena, Diop Mamadou, Doré Ahmadou, Soumah Fodé Y, Kourouma Kaka, Vielle Nathalie J, Loucoubar Cheikh, Camara Ibrahima, Kourouma Karifa, Annibaldis Giuditta, Bah Assaïtou, Thielebein Anke, Pahlmann Meike, Pullan Steven T, Carroll Miles W, Quick Joshua, Formenty Pierre, Legand Anais, Pietro Karla, Wiley Michael R, Tordo Noel, Peyrefitte Christophe, McCrone John T, Rambaut Andrew, Sidibé Youssouf, Barry Mamadou D, Kourouma Madeleine, Saouromou Cé D, Condé Mamadou, Baldé Moussa, Povogui Moriba, Keita Sakoba, Diakite Mandiou, Bah Mamadou S, Sidibe Amadou, Diakite Dembo, Sako Fodé B, Traore Fodé A, Ki-Zerbo Georges A, Lemey Philippe, Günther Stephan, Kafetzopoulou Liana E, Sall Amadou A, Delaporte Eric, Duraffour Sophie, Faye Ousmane, Leendertz Fabian H, Peeters Martine, Toure Abdoulaye, Magassouba N' Faly. Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks.. Nature. 2021. DOI: 10.1038/s41586-021-03901-9.

Предметные рубрики MeSH

AnimalsDemocratic Republic of the CongoDisease OutbreaksEbolavirusFemaleGuineaHemorrhagic Fever, EbolaHigh-Throughput Nucleotide SequencingHumansMaleModels, BiologicalPersistent InfectionPhylogenySurvivorsTime FactorsViral Zoonoses
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