Journal of the American Geriatrics Society · 2026
Lower Urinary Tract Symptoms and Cognitive Impairment Among Participants in the REGARDS Cohort Study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
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Markland Alayne D, Kennedy Richard, Crowe Michael, Williams Belinda, Munoz Cami, Elgayar Sara, Burgio Kathryn L, Howard Virginia J
Аннотация
BACKGROUND: To understand cross-sectional associations between lower urinary tract symptoms (LUTS) and specific cognitive domains, we examined cognitive performance in older adults with and without LUTS.
METHODS: The study comprised a subset of Black and White participants, aged 45 and older, enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) national, longitudinal cohort study 2003-2007. Computer-assisted telephone interviews were conducted for follow-up every 6 months including an established cognitive battery: Six-Item Screener (SIS) for cognitive impairment, animal naming, letter F naming, word list learning, and delayed recall for verbal fluency/executive function and verbal memory. Validated LUTS questionnaires were administered beginning in 2020 at 6-month intervals. Separate linear and logistic regression models for men and women estimated associations between LUTS and cognitive battery scores, adjusting for covariates.
RESULTS: From the 10,464 participants (6026 women, 4438 men), 70% of women reported LUTS (mean age 69 ± 8 years) versus 62% of men (mean age 63 ± 7 years). More Black men reported LUTS compared to White men, 69% versus 59% (p < 0.001), respectively, without differences among Black and White women. Men and women with LUTS had decreased odds of being cognitively intact based on the SIS, OR 0.65, 95% CI 0.50, 0.85 and OR 0.64, 95% CI 0.46, 0.78, respectively. Men with LUTS had lower scores for Animal Naming (β -0.42, 95% CI -0.75, -0.08) and Delayed Recall (β -0.18, 95% CI -0.30, -0.05). Women with LUTS had lower test scores for Letter F Naming (β -0.29, 95% CI -0.55, -0.04), Word List Learning (β -0.40, 95% CI -0.68, -0.11) and Delayed Recall (β -0.13, 95% CI -0.25, -0.02).
CONCLUSIONS: Older adults with LUTS have subtle differences in cognitive function, especially in new learning, verbal memory, and verbal fluency/executive function that should be considered in treatment decisions.
METHODS: The study comprised a subset of Black and White participants, aged 45 and older, enrolled in the REasons for Geographic and Racial Differences in Stroke (REGARDS) national, longitudinal cohort study 2003-2007. Computer-assisted telephone interviews were conducted for follow-up every 6 months including an established cognitive battery: Six-Item Screener (SIS) for cognitive impairment, animal naming, letter F naming, word list learning, and delayed recall for verbal fluency/executive function and verbal memory. Validated LUTS questionnaires were administered beginning in 2020 at 6-month intervals. Separate linear and logistic regression models for men and women estimated associations between LUTS and cognitive battery scores, adjusting for covariates.
RESULTS: From the 10,464 participants (6026 women, 4438 men), 70% of women reported LUTS (mean age 69 ± 8 years) versus 62% of men (mean age 63 ± 7 years). More Black men reported LUTS compared to White men, 69% versus 59% (p < 0.001), respectively, without differences among Black and White women. Men and women with LUTS had decreased odds of being cognitively intact based on the SIS, OR 0.65, 95% CI 0.50, 0.85 and OR 0.64, 95% CI 0.46, 0.78, respectively. Men with LUTS had lower scores for Animal Naming (β -0.42, 95% CI -0.75, -0.08) and Delayed Recall (β -0.18, 95% CI -0.30, -0.05). Women with LUTS had lower test scores for Letter F Naming (β -0.29, 95% CI -0.55, -0.04), Word List Learning (β -0.40, 95% CI -0.68, -0.11) and Delayed Recall (β -0.13, 95% CI -0.25, -0.02).
CONCLUSIONS: Older adults with LUTS have subtle differences in cognitive function, especially in new learning, verbal memory, and verbal fluency/executive function that should be considered in treatment decisions.