Epigenomics · 2025
Relationship stress and epigenetic age acceleration among older U.S. adults in the Midlife in the United States study.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rodrigues Mariana, Bather Jemar R, Cuevas Adolfo G
Аннотация
BACKGROUND: Chronic interpersonal stress has been linked to accelerated biological aging, but questions remain about which relationship stress domains may be most consequential during midlife.
RESEARCH DESIGN AND METHODS: Linear regression models quantified the cross-sectional associations between domain-specific relationship stressors (marital risk, partner strain, family strain, friendship strain) and next-generation epigenetic clocks (DunedinPACE and GrimAge2) in 1,310 midlife adults from the Midlife in the United States study (mean age = 51, SD = 13).
RESULTS: Controlling for sociodemographic and health behaviors, we found that friendship strain was uniquely associated with accelerated aging (GrimAge2: 0.03 SD increase, 95% CI: 0.01, 0.05, p = 0.003; DunedinPACE: 0.05 SD increase, 95% CI: 0.01, 0.09, p = 0.030). No statistically significant associations were observed for the other stressors with GrimAge2 or DunedinPACE in fully adjusted models.
CONCLUSIONS: These findings identify friendship strain as a potential specific risk factor for accelerated biological aging in midlife. Future research should investigate behavioral and physiological mechanisms linking friendship quality to cellular aging.
RESEARCH DESIGN AND METHODS: Linear regression models quantified the cross-sectional associations between domain-specific relationship stressors (marital risk, partner strain, family strain, friendship strain) and next-generation epigenetic clocks (DunedinPACE and GrimAge2) in 1,310 midlife adults from the Midlife in the United States study (mean age = 51, SD = 13).
RESULTS: Controlling for sociodemographic and health behaviors, we found that friendship strain was uniquely associated with accelerated aging (GrimAge2: 0.03 SD increase, 95% CI: 0.01, 0.05, p = 0.003; DunedinPACE: 0.05 SD increase, 95% CI: 0.01, 0.09, p = 0.030). No statistically significant associations were observed for the other stressors with GrimAge2 or DunedinPACE in fully adjusted models.
CONCLUSIONS: These findings identify friendship strain as a potential specific risk factor for accelerated biological aging in midlife. Future research should investigate behavioral and physiological mechanisms linking friendship quality to cellular aging.