Intensive Care Unit-Like Care of Nonhuman Primates with Ebola Virus Disease.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Blair Paul W, Kortepeter Mark G, Downey Lydia G, Madar Cristian S, Downs Isaac L, Martins Karen A, Rossi Franco, Williams Janice A, Madar Annie, Schellhase Christopher W, Bearss Jeremy J, Zeng Xiankun, Bavari Sina, Soloveva Veronica, Wells Jay B, Stuthman Kelly S, Garza Nicole L, Vantongeren Sean A, Donnelly Ginger C, Steffens Jesse, Kalapaca Jennifer, Wiseman Perry, Henry Joseph, Marko Shannon, Chappell Mark, Lugo-Roman Luis, Ramos-Rivera Elliot, Hofer Christian, Blue Eugene, Moore Joshua, Fiallos Jimmy, Wetzel Darrel, Pratt William D, Unangst Tami, Miller Adele, Sola James J, Reisler Ronald B, Cardile Anthony P
Аннотация
METHODS: Fourteen rhesus macaques were challenged intramuscularly with a target dose of Ebola virus (1000 plaque-forming units; Kikwit). NHPs were allocated to intensive care unit (ICU)-like algorithms (n = 7), intravenous fluids plus levofloxacin (n = 2), or a control group (n = 5). The primary outcome measure was duration of survival, and secondary outcomes included changes in clinical laboratory values.
RESULTS: Duration of survival was not significantly different between the pooled ICU-like algorithm and control groups (8.2 vs 6.9 days of survival; hazard ratio; 0.50; P = .25). Norepinephrine was effective in transiently maintaining baseline blood pressure. NHPs treated with ICU-like algorithms had delayed onset of liver and kidney injury.
CONCLUSIONS: While an obvious survival difference was not observed with ICU-like care, clinical observations from this model may aid in EVD supportive care NHP model refinement.