Case reports in dermatology · 2025
A Case Report of Non-Uremic Calciphylaxis Refractory to Treatment Requiring Multidisciplinary Care.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Lee Ryan, Kahn Hannah, Aiad Mina, Wilson Melissa
Аннотация
INTRODUCTION: Calciphylaxis, also known as calcific uremic arteriolopathy, is a rare, severe disease that causes diffuse skin ischemia and necrotic lesions with a high mortality rate. This disease most commonly affects patients with end-stage renal disease (ESRD). However, there are reported cases of patients developing calciphylaxis without ESRD, known as non-uremic calciphylaxis (NUC). NUC is especially rare, and little is known about its pathophysiology and treatment.
CASE PRESENTATION: We present the case of a 47-year-old male with multiple comorbidities but no history of ESRD who presented initially with left leg lesions eventually diagnosed as calciphylaxis. Multimodal treatment with extensive rehabilitation and multiple amputations, along with palliative care, was necessary as the patient did not respond to standard treatment of thiosulfate.
CONCLUSION: NUC is a rare disease, and awareness of its existence is essential for earlier diagnosis and optimal management.
CASE PRESENTATION: We present the case of a 47-year-old male with multiple comorbidities but no history of ESRD who presented initially with left leg lesions eventually diagnosed as calciphylaxis. Multimodal treatment with extensive rehabilitation and multiple amputations, along with palliative care, was necessary as the patient did not respond to standard treatment of thiosulfate.
CONCLUSION: NUC is a rare disease, and awareness of its existence is essential for earlier diagnosis and optimal management.