Primary intracerebral pleomorphic liposarcoma in a young male.

Liposarcoma is the commonest soft tissue neoplasm, usually located in the deep soft tissue of the limbs. The central nervous system (CNS) as the primary site is exceedingly rare. We report a 35-year-old male patient who presented with seizure and weakness of the left half of the body for three months. The magnetic resonance imaging of the brain revealed a large solid partially necrotic lesion in the right posterior frontal lobe with perilesional edema. The tumour was firm, intra-axial, not adherent to the dura, and was completely excised. Based on the morphology, immunohistochemistry, and imaging findings, the diagnosis of primary intracerebral pleomorphic liposarcoma was rendered. Post-operatively, the patient had an uneventful follow-up. Pleomorphic liposarcoma is a rare CNS tumor with aggressive behavior, high potential for local recurrence, and distant metastasis. However, the acquaintance with intracranial liposarcoma is limited because of its rarity, and thus, no standard treatment protocol is of consensus.