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The Medical journal of Australia · 2026

Deprescribing in Older People: A Clinical Practice Guideline Summary.

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Quek Hui Wen, Reus Perello Xisco, Lee Kenneth, Abraham Atinuke, Adams Leon A, Almeida Osvaldo P, Almutairi Hend, Armstrong Bree, Boase Leanne, Breen Juanita, Brown Lauren J, Caughey Gillian E, Chan Lewis W, Chen Roger, Chew Edward, Clark Antony, Comans Tracy, Criddle Deirdre, Dārziņš Pēteris, Dawda Paresh, Doust Jenny A, Edwards Sue, Gowan Jennifer, Hart Kerryn, Hawthorne Deborah, Heredia Andrew, Hill Anne-Marie, Jansen Jesse, Kalisch Ellett Lisa, Keen Helen, Kelty Erin A, Kerse Ngaire M, Kruger Estie, Kurrle Susan E, Lance Howard, Livori Adam, Livori Rebecca, LoGiudice Dina C, Mangoni Arduino A, Marinucci Anthony, McKay Nilufeur, Mckendrick Allison M, McLachlan Andrew J, McGuire Treasure M, Mearns Stewart, Morgan Mark, Nabi Saba, Naganathan Vasi, Newman Elaine, Ng Christopher A C M, Osborne Maz, Parkin Ray, Polkinghorne Kevan R, Pond Constance Dimity, Potter Kathleen, Rigby Debbie, Rowett Debra, Schipp Amina, Seda Veronika, Seeto Jessica, Shakib Sepehr, Shiu Angela, Stafford Andrew C, Tan Irene J, Tennant Marc, Teoh Leanne, Tucker Stephen, Watson John D G, Wellins Donna, Whitmore Tim, Etherton-Beer Christopher, Page Amy T

Аннотация

INTRODUCTION: Older people face higher risks of medicine-related harm due to polypharmacy and the use of potentially inappropriate medicines. Current treatment guidelines rarely specify when to stop medicines, leading to medicines often being continued indefinitely without a clear deprescribing plan. While deprescribing guidelines exist for some medicine classes, limited guidance is a major barrier to deprescribing. These new guidelines address this gap by providing structured recommendations that complement more detailed drug-specific deprescribing guidance, disease-specific therapeutic guidelines and non-pharmacological management resources. These guidelines were developed by a team of 72 experts, including consumer representatives, and were further shaped by feedback from public consultation and independent reviewers.

MAIN RECOMMENDATIONS: The guidelines are intended for all healthcare professionals involved in prescribing, dispensing or administering medicines to older people. The guidelines specifically address polypharmacy and medicines commonly dispensed for regular use in people aged ≥ 65 years, as well as other medicines where there is evidence to consider deprescribing in this cohort. The guidelines provide 185 consensus-based recommendations and 70 good practice statements, covering both specific medicine categories and general deprescribing principles. The guidelines are structured into four areas: (1) when to deprescribe; (2) ongoing treatment needs; (3) how to deprescribe; and (4) monitoring requirements.

CHANGES IN CARE AS A RESULT OF THE GUIDELINE: This guideline emphasises deprescribing as an integral part of the prescribing continuum. Applying a deprescribing approach encourages prescribers to consider the ongoing need for a medicine each time a prescription is re-issued, to balance benefits and harms as they evolve over time, and to ensure treatment decisions reflect an individual's goals through shared decision-making. The guideline was developed based on currently available evidence for deprescribing and expert multidisciplinary and consumer input. It supports health professionals in reviewing regular medicines, minimising harm and planning ongoing treatment or monitoring. The detailed guideline is available at https://deprescribing.com.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты