Journal of psychiatric research · 2025
Pre-pandemic psychiatric disorders, disease specific polygenic scores, and alcohol consumption patterns during the COVID-19 pandemic.
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Christoffersen Lea Arregui Nordahl, Quinn Liam, Brodersen Thorsten, Loft Isabella, Jensen Bitten Aagaard, Erikstrup Christian, Mikkelsen Christina, DBDS Genetic Consortium, Sørensen Erik, Kranzler Henry R, Kaspersen Kathrine Agergård, Didriksen Maria, Ostrowski Sisse Rye, Werge Thomas, Helenius Dorte, Pedersen Ole B
Аннотация
BACKGROUND: Pre-pandemic psychiatric disorders have been associated with elevated alcohol consumption during the COVID-19 pandemic, raising concerns about associated morbidity and mortality; however, insight into the mechanisms is lacking.
METHODS: In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.
RESULTS: Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.
CONCLUSION: Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.
METHODS: In this prospective cohort study with multiple follow-ups of 27,208 participants from the Danish Blood Donor Study, the potential genetic influence on the associations of pre-pandemic alcohol use disorders (AUD) and major depressive disorder (MDD) with pandemic alcohol consumption patterns was assessed in Poisson regression models, using polygenic scores (PGS). Information on pre-pandemic psychiatric disorders was obtained from Danish national health registers, while information on alcohol consumption was obtained through questionnaires.
RESULTS: Adjustment for PGSs did not impact the association of pre-pandemic AUD with alcohol consumption patterns during the COVID-19 pandemic at any time points (e.g., unadjusted [B = 0.68; 95 %CI: 0.52; 0.84] vs. adjusted for AUD PGS [B = 0.66; 95 %CI: 0.50; 0.82]. However, higher AUD PGSs were associated with higher alcohol consumption among individuals without pre-pandemic AUD. Pre-pandemic MDD was unrelated to alcohol consumption patterns during the COVID-19 pandemic in all analyses.
CONCLUSION: Genetic liability to AUD was associated with increased alcohol consumption during the COVID-19 pandemic but only among individuals without pre-pandemic AUD.