Experimental dermatology · 2014
Co-occurrence of autoantibodies in healthy blood donors.
Письмо в редакциюПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Prüßmann Jasper, Prüßmann Wiebke, Recke Andreas, Rentzsch Kristin, Juhl David, Henschler Reinhard, Müller Susen, Lamprecht Peter, Schmidt Enno, Csernok Elena, Görg Siegfried, Stöcker Winfried, Zillikens Detlef, Ibrahim Saleh M, Ludwig Ralf J
Аннотация
Autoimmune diseases are rare, but their incidence has increased over the past decades. Interestingly, the co-occurrence of autoimmune diseases is well documented; however, data on the presence of more than one specific autoantibody in healthy individuals are not available. Here, we investigated the prevalence of several autoantibodies in a cohort of over 6000 healthy persons. While individual autoantibodies were rarely detected (i.e. ranging from 0.3% for ANCA to 4.6% for anti-TPO), the cumulative prevalence of the tested autoantibodies was as high as 10%. Furthermore, our results demonstrate co-occurrence of ANA with specific autoantibodies that target TPO, CCP and Dsg1/3, while ANCA and autoantibodies to PCA and BP180/BP230 were not more frequent in ANA-positive compared to ANA-negative samples. This indicates that shared and independent mechanisms influence loss of tolerance to distinct sets of self-antigens.