European journal of pain (London, England) · 2025
Pain in Parkinson's disease is impacted by motor complications, anxiety and sleep disturbances.
СтатьяНаблюдательное исследованиеМногоцентровое исследованиеНазвание и аннотация: Перевод в очереди
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Rukavina Katarina, Staunton Juliet, Zinzalias Pavlos, Skoric Magdalena Krbot, Poplawska-Domaszewicz Karolina, Pisani Antonio, Bannister Kirsty, Chaudhuri K Ray
Аннотация
BACKGROUND: Parkinson's disease (PD) is the second most common neurodegenerative disease. Over two thirds of People with Parkinson's (PwP) live with chronic PD-related pain, but its successful management remains an unmet need. Unrevealing links between pain and other motor and non-motor symptoms (NMS) of PD may accelerate delivery of much needed precision pain medicine approaches for PwP.
METHODS: An exploratory, cross-sectional analysis of the prospective, observational, multicentre, international study 'The Non-motor International Longitudinal, Real-Life Study in PD - NILS'.
RESULTS: In 109 PwP (41.3% women, age 64.29 ± 9.80 years, disease duration 5.50 (2.44-10.89) years, H&Y stage 2 (1-4), levodopa equivalent daily dose 575.00 (315.00-1004.00) mg), strong correlations were noted between the total burden of PD-related pain and the total NMS burden (rs = 0.641) and moderate with disturbances of sleep/fatigue (rs = 0.483), cognitive issues (rs = 0.445), motor complications (rs = 0.421), anxiety (rs = 0.441) and depression (rs = 0.451). In a multivariate linear regression analysis, motor complications (B = 2.063, 95% CI for B 1.152-2.974, p < 0.001), sleep disturbances/fatigue (B = 0.392, 95% CI for B 0.064-0.720, p = 0.020) and anxiety (B = 0.912, 95% CI for B 0.165-1.659, p = 0.017) significantly impacted the overall burden of pain.
CONCLUSIONS: In PwP, PD-related pain is significantly impacted by motor complications, anxiety and sleep disturbances. A personalized, tailored approach to management of pain in PwP need to accurately identify and tackle all its interrelated symptoms. Whether successful management of motor complications, anxiety and sleep disturbances may contribute to pain relief in PwP for specified cohorts needs to be a focus of future randomized controlled clinical trials.
SIGNIFICANCE STATEMENT: This explorative analysis identifies the frequent overlap of chronic pain, motor complications, sleep disturbances and anxiety in Parkinson's disease and could help advance the development of precise and effective pain management strategies tailored to the needs of People with Parkinson's.
METHODS: An exploratory, cross-sectional analysis of the prospective, observational, multicentre, international study 'The Non-motor International Longitudinal, Real-Life Study in PD - NILS'.
RESULTS: In 109 PwP (41.3% women, age 64.29 ± 9.80 years, disease duration 5.50 (2.44-10.89) years, H&Y stage 2 (1-4), levodopa equivalent daily dose 575.00 (315.00-1004.00) mg), strong correlations were noted between the total burden of PD-related pain and the total NMS burden (rs = 0.641) and moderate with disturbances of sleep/fatigue (rs = 0.483), cognitive issues (rs = 0.445), motor complications (rs = 0.421), anxiety (rs = 0.441) and depression (rs = 0.451). In a multivariate linear regression analysis, motor complications (B = 2.063, 95% CI for B 1.152-2.974, p < 0.001), sleep disturbances/fatigue (B = 0.392, 95% CI for B 0.064-0.720, p = 0.020) and anxiety (B = 0.912, 95% CI for B 0.165-1.659, p = 0.017) significantly impacted the overall burden of pain.
CONCLUSIONS: In PwP, PD-related pain is significantly impacted by motor complications, anxiety and sleep disturbances. A personalized, tailored approach to management of pain in PwP need to accurately identify and tackle all its interrelated symptoms. Whether successful management of motor complications, anxiety and sleep disturbances may contribute to pain relief in PwP for specified cohorts needs to be a focus of future randomized controlled clinical trials.
SIGNIFICANCE STATEMENT: This explorative analysis identifies the frequent overlap of chronic pain, motor complications, sleep disturbances and anxiety in Parkinson's disease and could help advance the development of precise and effective pain management strategies tailored to the needs of People with Parkinson's.